甲基4-脱氧-4-氟-alpha-D-葡萄糖三苯甲酸酯合成路线 （共 4 条）
反应条件
methanesulfonic acid; cesium fluoride; tetrabutyl ammonium fluoride in 1,1-dimethylpropan-1-ol T=70°C;
参考文献
SANOFI-AVENTIS; GESSLER, Simon; GILL, Harpal S.; LEE, George E.; PLETTENBURG, Oliver; PODESCHWA, Michael; POWERS, Matthew R.; ROSSEN, Kai; SHRIMP, II, Frederick L.; SUBOTKOWSKI, Witold; VANASSE, Benoit J.; WEHLAN, Hermut A.; WEIBERTH, Franz J.; YU, Yong; ZHANG, Jiuqing
Patent: WO2010/77623 A1, 2010 ;
Location in patent: Page/Page column 53 ;
反应条件
[bis(2-methoxyethyl)amino]-sulfur trifluoride in tetrahydrofuran T=20 - 52°C; Large scale reaction;
参考文献
Weiberth, Franz J.; Gill, Harpal S.; Jiang, Ying; Lee, George E.; Lienard, Philippe; Pemberton, Clive; Powers, Matthew R.; Subotkowski, Witold; Tomasik, Witold; Vanasse, Benoit J.; Yu, Yong
Organic Process Research and Development, 2010 , vol. 14, # 3 p. 623 - 631
反应条件
1: 61 percent / pyridine 2: 50.5 percent / DAST / CH2Cl2 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 23 p. 6994 - 6998
反应条件
sodium methylate in methanol Ambient temperature;
参考文献
Carbohydrate research, , vol. 169, p. 23 - 34
