2-(氯甲基)-4-甲氧基-3,5-二甲基吡啶合成路线 （共 9 条）
反应条件
thionyl chloride in dichloromethane T=25°C; 2 h;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 3 p. 438 - 450
反应条件
1: With p-toluenesulfonyl chloride in dichloromethane T=40°C; 2 h; 2: With triethylamine in dichloromethane T=40°C; 3 h;
参考文献
Synthetic Communications, , vol. 32, # 8 p. 1211 - 1217
反应条件
1: 2N aq. NaOH / methanol / 2 h / 25 °C 2: SOCl2 / CH2Cl2 / 2 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 3 p. 438 - 450
反应条件
1: 2 N NaOH / ethanol / 50 °C 2: 3-chloroperoxybenzoic acid / CH2Cl2 / 2 h / -30 °C View Scheme
参考文献
Senn-Bilfinger; Kruger; Sturm; Figala; Klemm; Kohl; Rainer; Schaefer; Blake; Darkin; Ife; Leach; Mitchell; Pepper; Salter; Viney; Huttner; Zsolnai
Journal of Organic Chemistry, 1987 , vol. 52, # 20 p. 4582 - 4592
反应条件
sodium hydroxide in tetrahydrofuran T=40°C; 5 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 8, # 14 p. 1909 - 1912
反应条件
in methanol 4 h; Heating;
参考文献
Rane; Pathak; Kaushik; Prasad Rao; Kumar, Ashok
Synthetic Communications, 2002 , vol. 32, # 8 p. 1211 - 1217
反应条件
1: 3,5-dimethyl-4-methoxy-pyridin-2-ylmethyl chloride With [Mg(anthracene)(THF)3] in tetrahydrofuran T=-5 - 0°C; Inert atmosphere; 2: C10H12N2O3S in tetrahydrofuran T=-5 - 30°C; 4 h; Inert atmosphere;
参考文献
Bhalerao, Dinesh S.; Kondaiah, Golla China Mala; Dwivedi, Namrata; Mylavarappu, Ravi Kumar; Reddy, Lekkala Amarnath; Roy, Arnab; Nagaraju, Gudimalla; Reddy, Padi Pratap; Bhattacharya, Apurba; Bandichhor, Rakeshwar
Synthetic Communications, 2010 , vol. 40, # 20 p. 2983 - 2987
反应条件
1: 68 percent / aq. NaOH / tetrahydrofuran / 5 h / 40 °C 2: 91 percent / SeO2, pyridine / 2.5 h / Heating View Scheme
参考文献
Yoon, Sung-Hwa; Seo, SeungKi; Lee, YoungHee; Hwang, SungKwan; Kim, Dong Yeon
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 14 p. 1909 - 1912
反应条件
sodium hydroxide in dichloromethane; water
参考文献
Hoffman-La Roche Inc.
Patent: US4766133 A1, 1988 ;
