反应条件
1: 96 percent / KOH / dioxane; methanol / 2 h / 80 °C
2: SOCl2; DMAP / toluene / 1 h / Heating
3: 13.3 g / NH3(g) / CH2Cl2 / 20 °C
4: 94 percent / pyridine; TFAA / dioxane / 3 h / 20 °C
5: 99 percent / aq. LiOH / tetrahydrofuran / 1.5 h / 20 °C
6: 99 percent / (COCl)2 / toluene / 22 h / 70 °C
7: 96 percent / Et3N / CH2Cl2 / 2.75 h / 0 - 20 °C
View Scheme
参考文献
Wendt, Michael D.; Rockway, Todd W.; Geyer, Andrew; McClellan, William; Weitzberg, Moshe; Zhao, Xumiao; Mantei, Robert; Nienaber, Vicki L.; Stewart, Kent; Klinghofer, Vered; Giranda, Vincent L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 303 - 324
