benzophenone; potassium tert-butylate in toluene 16 h; Inert atmosphereReflux;

water; acetic acid; dihydrogen peroxide T=70 - 80°C;

water; oxygen presence/absence of water, O2, H2O2; other acids; other chinchona alkaloids; Product distributionMechanism;

1: isopropyl alcohol With potassium tert-butylate; oxygen in tetrahydrofuran T=0°C; 1 h; 2: quininone With oxygen in tetrahydrofuran T=0 - 20°C;

1.1: potassium tert-butylate; oxygen / tetrahydrofuran / 0.67 h / 0 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere 3.1: thionyl chloride / dichloromethane / 2 h / 0 °C / Inert atmosphere; Reflux 4.1: potassium carbonate; sodium iodide / acetonitrile / 2 h / Inert atmosphere; Reflux 5.1: trifluoroacetic acid / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere 5.3: -78 - 20 °C 6.1: pyridine / chloroform / Inert atmosphere 7.1: potassium tert-butylate / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 2.5 h / Inert atmosphere; Reflux View Scheme