1-[4-(二氟甲氧基)苯基]乙酮合成路线 （共 7 条）
反应条件
sodium hydroxide in 1,4-dioxane; water
反应条件
sodium hydroxide; tetra-(n-butyl)ammonium iodide in 1,4-dioxane; water
反应条件
potassium hydroxide in dichloromethane; water T=0°C; 0.5 h;
参考文献
Li, Lingchun; Wang, Fei; Ni, Chuanfa; Hu, Jinbo
Angewandte Chemie - International Edition, 2013 , vol. 52, # 47 p. 12390 - 12394
Angew. Chem., 2013 , vol. 125, # 47 p. 12616 - 12620,5
反应条件
in N-methyl-acetamide; diethyl ether; 1-chloro-1,1-difluoro-methane; water
反应条件
sodium hydroxide; tri[2-(2-methoxyethoxy)ethyl]amine in toluene T=105°C; 1.17 h; Yield given;
参考文献
Journal of Fluorine Chemistry, , vol. 41, p. 247 - 262
反应条件
bromine in 1,4-dioxane T=20°C; 1 h;
参考文献
Genentech, Inc.; Array BioPharma Inc.; Blake, Jim; Chen, Huifen; Chicarelli, Mark; Gaudino, John; Gazzard, Lewis; Kintz, Sam; Mohr, Pete; Robarge, Kirk; Schwarz, Jacob; Zhou, Aihe
Patent: US2014/66453 A1, 2014 ;
Location in patent: Paragraph 0478-0479 ;
反应条件
ammonia; hydrogen; nickel in methanol T=100 - 120°C; Reduction; P=30400 Torr; 6 h;
参考文献
Yamanaka; Moritomo; Fujii; Tanaka; Fukuda; Nishimura
Pesticide Science, 1998 , vol. 54, # 3 p. 223 - 229
