2-正丁基-4-氯-5-甲酰基咪唑合成路线 （共 45 条）
反应条件
sodium hydroxide; sodium tetrahydroborate in water; toluene
参考文献
US5128355 A1, ;
US 5128355 A
反应条件
1: With potassium carbonate in N,N-dimethyl-formamide T=20 - 22°C; 3 h; 2: With sodium tetrahydroborate in water; N,N-dimethyl-formamide T=48 - 52°C; 3.08333 h;
参考文献
MEDICHEM, S.A.
Patent: WO2007/20533 A2, 2007 ;
Location in patent: Page/Page column 11-12 ;
反应条件
sodium borohydride in water; ethyl acetate; acetone
参考文献
E. I. Du Pont de Nemours and Company; Merck and Co., Inc.
Patent: US5310928 A1, 1994 ;
US 5310928 A
Title/Abstract Full Text Show Details
Lo; Young S.; Rossano; Lucius T.
Patent: US5130439 A1, 1992 ;
US 5130439 A
反应条件
1: 1.) K2CO3, 2.) NaBH4 / 1.) dimethylacetamide, -10 deg C, 2 h; room temp., 2 h, 2.) MeOH, room temp., 1 h View Scheme
参考文献
Carini, David J.; Duncia, John V.; Aldrich, Paul E.; Chiu, Andrew T.; Johnson, Alexander L.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2525 - 2547
反应条件
1: K2CO3 / dimethylformamide / 1 h / 70 °C 2: 1.) H2, KOAc, 2.) MnO2 / 1.) 10percent Pd/C / 1.) MeOH, 40 psi, 1.25 h, 2.) CH2Cl2, reflux 3: 1.) LDA / 1.) THF, hexane, -78 deg C, 60 min, 2.) THF, hexane, -78 deg C, 10 min 4: (dimethylamino)pyridine / CH2Cl2 / 19 h 5: DBU / toluene / 1 h / 100 °C 6: 70 percent / 10percent aq. NaOH / ethanol / 17 h / Ambient temperature View Scheme
参考文献
Weinstock, Joseph; Keenan, Richard M.; Samanen, James; Hempel, Judith; Finkelstein, Joseph A.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1514 - 1517
反应条件
1: K2CO3 / dimethylformamide 2: H2 / Pd/C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 24 p. 8449 - 8454
反应条件
1: 49 percent / potassium carbonate / dimethylformamide / 24 h / 25 °C 2: 10percent HCl / tetrahydrofuran / 4 h / 25 °C View Scheme
参考文献
Carini, David J.; Duncia, John V.; Aldrich, Paul E.; Chiu, Andrew T.; Johnson, Alexander L.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2525 - 2547
反应条件
1: K2CO3 / dimethylformamide / 1 h / 70 °C 2: 1.) H2, KOAc, 2.) MnO2 / 1.) 10percent Pd/C / 1.) MeOH, 40 psi, 1.25 h, 2.) CH2Cl2, reflux 3: 1.) LDA / 1.) THF, hexane, -78 deg C, 60 min, 2.) THF, hexane, -78 deg C, 10 min 4: (dimethylamino)pyridine / CH2Cl2 / 19 h 5: DBU / toluene / 1 h / 100 °C View Scheme
参考文献
Weinstock, Joseph; Keenan, Richard M.; Samanen, James; Hempel, Judith; Finkelstein, Joseph A.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1514 - 1517
反应条件
1: 49 percent / potassium carbonate / dimethylformamide / 24 h / 25 °C 2: sodium borohydride / CH2Cl2 / 24 h / 25 °C 3: 89 percent / 10percent HCl / tetrahydrofuran / 4 h / 25 °C View Scheme
参考文献
Carini, David J.; Duncia, John V.; Aldrich, Paul E.; Chiu, Andrew T.; Johnson, Alexander L.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2525 - 2547
反应条件
sodium borohydride; potassium carbonate in isobutyramide; water
参考文献
E. I. Du Pont de Nemours and Company; Merck and Co., Inc.
Patent: US5310928 A1, 1994 ;
US 5310928 A
