2-正丁基-4-氯-5-甲酰基咪唑合成路线 （共 45 条）
反应条件
potassium hydroxide in water; acetic acid
参考文献
Hoechst Aktiengesellschaft
Patent: US5482957 A1, 1996 ;
US 5482957 A
反应条件
1: glycine With sodium hydroxide in methanol T=0°C; 0.25 h; 2: methyl pentanimidate in methanol T=0 - 20°C; 16.16 - 16.25 h; 3: N,N-dimethyl-formamide With sodium hydroxide; water; trichlorophosphate; copper(II) bis(trifluoromethanesulfonate) Product distribution / selectivity; more than 3 stages;
参考文献
DISHMAN PHARMACEUTICALS AND CHEMICALS LTD; Henk Plum
Patent: US2008/200690 A1, 2008 ;
Location in patent: Page/Page column 4-5 ;
反应条件
ammonium cerium(IV) nitrate in acetic acid T=25°C; 3 h;
参考文献
Carini, David J.; Duncia, John V.; Aldrich, Paul E.; Chiu, Andrew T.; Johnson, Alexander L.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2525 - 2547
反应条件
NH4Ca(NO3)3; sodium hydroxide in acetic acid
参考文献
US5128355 A1, ;
US 5128355 A
反应条件
hydrogenchloride; sodium hydroxide in methanol
反应条件
trichlorophosphate T=100°C; Substitution; 1.5 h;
参考文献
Griffiths, Gareth J.; Hauck, Michael B.; Imwinkelried, Rene; Kohr, Joerg; Roten, Conrad A.; Stucky, Gerhard C.; Gosteli, Jacques
Journal of Organic Chemistry, 1999 , vol. 64, # 22 p. 8084 - 8089
反应条件
hydrogenchloride; sodium hydroxide in water
反应条件
trichlorophosphate in toluene T=100°C; Dehydrogenation; Vilsmeier formylation; chlorination; 2 h;
参考文献
Griffiths, Gareth J.; Hauck, Michael B.; Imwinkelried, Rene; Kohr, Joerg; Roten, Conrad A.; Stucky, Gerhard C.; Gosteli, Jacques
Journal of Organic Chemistry, 1999 , vol. 64, # 22 p. 8084 - 8089
反应条件
manganese(IV) dioxide in tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide
参考文献
US5322950 A1, ;
US 5322950 A
反应条件
trichlorophosphate in toluene T=100°C; Cyclization; Vilsmeier formylation; substitution; 2 h;
参考文献
Griffiths, Gareth J.; Hauck, Michael B.; Imwinkelried, Rene; Kohr, Joerg; Roten, Conrad A.; Stucky, Gerhard C.; Gosteli, Jacques
Journal of Organic Chemistry, 1999 , vol. 64, # 22 p. 8084 - 8089
