反应条件
1: 2-(4-bromophenyl)-2-methylpropionic acid With sodium hydride in tetrahydrofuran T=25°C; deprotonation; 0.5 h; 2: With tert.-butyl lithium in tetrahydrofuran T=-72°C; Metallation; 0.916667 h; 3: 4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyraldehyde in tetrahydrofuran T=-72°C; Condensation; 2.5 h;
参考文献
Patel, Sunil; Waykole, Liladhar; Repic, Oljan; Chen, Kau-Ming
Synthetic Communications, 1996 , vol. 26, # 24 p. 4699 - 4710
