5-甲氧基吲哚-3-丁酸合成路线 （共 11 条）
反应条件
potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate in 1,2,3,4-tetrahydro-naphthalene; octanol 4 h; Heating;
参考文献
Csende, Ferenc
Archiv der Pharmazie (Weinheim, Germany), 2001 , vol. 334, # 7 p. 253 - 254
参考文献
Clack, Denis W.; Jackson, Anthony H.; Prasitpan, Noojaree; Shannon, Patrick V. R.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1982 , p. 909 - 916
反应条件
1: 95 percent / sodium hydroxide / ethanol / 0.5 h / Heating 2: 59 percent / 0.25 h / 235 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 909 - 916
反应条件
1: sodium nitrite; sodium tetrafluoroborate; hydrogenchloride / 0 °C 2: sodium hydride / tetrahydrofuran / |Reflux 3: hydrogenchloride / ethanol / |Reflux 4: sodium hydroxide / ethanol / |Reflux 5: neat (no solvent) / 220 °C View Scheme
参考文献
Chemical Communications (Cambridge, United Kingdom), , vol. 48, # 84 p. 10398 - 10400,3
Chemical Communications, , vol. 48, # 84 p. 10398 - 10400
反应条件
1: sodium hydride / tetrahydrofuran / |Reflux 2: hydrogenchloride / ethanol / |Reflux 3: sodium hydroxide / ethanol / |Reflux 4: neat (no solvent) / 220 °C View Scheme
参考文献
Chemical Communications (Cambridge, United Kingdom), , vol. 48, # 84 p. 10398 - 10400,3
Chemical Communications, , vol. 48, # 84 p. 10398 - 10400
反应条件
1: hydrogenchloride / ethanol / |Reflux 2: sodium hydroxide / ethanol / |Reflux 3: neat (no solvent) / 220 °C View Scheme
参考文献
Chemical Communications (Cambridge, United Kingdom), , vol. 48, # 84 p. 10398 - 10400,3
Chemical Communications, , vol. 48, # 84 p. 10398 - 10400
反应条件
1: 45 percent / hydrogen chloride / ethanol / 1.) reflux, 15 min, 2.) 20 deg C 2: 95 percent / sodium hydroxide / ethanol / 0.5 h / Heating 3: 59 percent / 0.25 h / 235 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 909 - 916
反应条件
1: ethanol / Erwaermen des Reaktionsprodukts mit H3PO4 in Methanol 2: ethanolic KOH View Scheme
参考文献
Doklady Akademii Nauk SSSR, , vol. 101, p. 103,105
Chem.Abstr., , p. 2543
反应条件
1: ethanol / Erwaermen des Reaktionsprodukts mit H3PO4 in Methanol 2: ethanolic KOH View Scheme
参考文献
Doklady Akademii Nauk SSSR, , vol. 101, p. 103,105
Chem.Abstr., , p. 2543
反应条件
1: 1.) N,N'-carbonyldiimidazole / 1.) THF, RT, 1 h, 2.) THF, RT, overnight 2: dihydrobis(methoxyethanato-O,O')aluminate sodium / tetrahydrofuran / 2 h / Ambient temperature 3: diisobutylaluminium hydride (DIBAH) / toluene / 1.5 h / Heating View Scheme
参考文献
Bottcher; Barnickel; Hausberg; Haase; Seyfried; Eiermann
Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4020 - 4026
