(S)-3-氨基-3-苯基丙酸盐酸盐合成路线 （共 21 条）
反应条件
1: N-methylmorpholine / 0.5 h / -5 °C 2: 51 percent / diethyl ether; tetrahydrofuran 3: 91 percent / Et3N, silver benzoate / 3 h 4: 77 percent / H2, conc. HCl / 10percent Pd/C / methanol / 3.5 h / 760 Torr / Ambient temperature 5: 74 percent / 10percent aq. NaOH / 3 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 17 p. 2047 - 2054
反应条件
1: 77 percent / H2, conc. HCl / 10percent Pd/C / methanol / 3.5 h / 760 Torr / Ambient temperature 2: 74 percent / 10percent aq. NaOH / 3 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 17 p. 2047 - 2054
反应条件
1: 91 percent / Et3N, silver benzoate / 3 h 2: 77 percent / H2, conc. HCl / 10percent Pd/C / methanol / 3.5 h / 760 Torr / Ambient temperature 3: 74 percent / 10percent aq. NaOH / 3 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 17 p. 2047 - 2054
反应条件
1: ammonium acetate / butan-1-ol 2: 85 percent / 1.) HCl, 2.) NaOH 4: 98 percent / 1) 40percent aq. NaOH, 2) conc HCl / 16 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 39, # 15 p. 2459 - 2464
反应条件
1.1: samarium diiodide / tetrahydrofuran / 2.17 h / -78 °C / Inert atmosphere 1.2: Inert atmosphere 2.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C View Scheme
参考文献
Science China Chemistry, , vol. 54, # 1 p. 61 - 65
反应条件
hydrogenchloride T=100°C; 1.5 h;
参考文献
Chemistry - A European Journal, , vol. 13, # 29 p. 8338 - 8351
反应条件
2: 98 percent / 1) 40percent aq. NaOH, 2) conc HCl / 16 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 39, # 15 p. 2459 - 2464
反应条件
1: 85 percent / 1.) HCl, 2.) NaOH 3: 98 percent / 1) 40percent aq. NaOH, 2) conc HCl / 16 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 39, # 15 p. 2459 - 2464
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 2 p. 167 - 174
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 2 p. 167 - 174
