顺式-1-N-BOC-4-甲氧基-L-脯氨酸合成路线 （共 11 条）
反应条件
hydrogenchloride; sodium hydroxide in N-methyl-acetamide; methanol; hexane; water
参考文献
Scios Inc.
Patent: US6288036 B1, 2001 ;
反应条件
1: With sodium hydroxide; water in tetrahydrofuran; methanol T=20°C; 2: With hydrogenchloride in water
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: WO2005/121135 A1, 2005 ;
Location in patent: Page/Page column 52 ;
反应条件
triethylamine; Pd-C in ethanol; hexane; dichloromethane; ethyl acetate
反应条件
lithium hydroxide in methanol; water T=20°C; 16 h;
参考文献
Taylor, Carol M.; Hardre, Renaud; Edwards, Patrick J. B.
Journal of Organic Chemistry, 2005 , vol. 70, # 4 p. 1306 - 1315
反应条件
palladium 10 on activated carbon; hydrogen in methanol 14 h;
参考文献
Shoulders, Matthew D.; Kotch, Frank W.; Choudhary, Amit; Guzei, Ilia A.; Raines, Ronald T.
Journal of the American Chemical Society, 2010 , vol. 132, # 31 p. 10857 - 10865
反应条件
1: 358 mg / sodium azide / methanol / 18 h / 40 °C 2: 48 percent / sodium hydride; 18-crown-6 / various solvent(s); tetrahydrofuran / 18 h / 20 °C 3: 84 percent / lithium hydroxide / methanol; H2O / 16 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 70, # 4 p. 1306 - 1315
反应条件
1.1: thionyl chloride / 16 h / Heating 1.2: 96 percent / triethylamine / CH2Cl2 / 17 h 2.1: triphenylphosphine; DIAD / tetrahydrofuran / 1.5 h / 0 °C 3.1: 358 mg / sodium azide / methanol / 18 h / 40 °C 4.1: 48 percent / sodium hydride; 18-crown-6 / various solvent(s); tetrahydrofuran / 18 h / 20 °C 5.1: 84 percent / lithium hydroxide / methanol; H2O / 16 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 70, # 4 p. 1306 - 1315
反应条件
1: triphenylphosphine; DIAD / tetrahydrofuran / 1.5 h / 0 °C 2: 358 mg / sodium azide / methanol / 18 h / 40 °C 3: 48 percent / sodium hydride; 18-crown-6 / various solvent(s); tetrahydrofuran / 18 h / 20 °C 4: 84 percent / lithium hydroxide / methanol; H2O / 16 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 70, # 4 p. 1306 - 1315
反应条件
1.1: thionyl chloride / 16 h / Heating 1.2: 96 percent / triethylamine / CH2Cl2 / 17 h 2.1: triphenylphosphine; DIAD / tetrahydrofuran / 1.5 h / 0 °C 3.1: 358 mg / sodium azide / methanol / 18 h / 40 °C 4.1: 48 percent / sodium hydride; 18-crown-6 / various solvent(s); tetrahydrofuran / 18 h / 20 °C 5.1: 84 percent / lithium hydroxide / methanol; H2O / 16 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 70, # 4 p. 1306 - 1315
反应条件
1: 48 percent / sodium hydride; 18-crown-6 / various solvent(s); tetrahydrofuran / 18 h / 20 °C 2: 84 percent / lithium hydroxide / methanol; H2O / 16 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 70, # 4 p. 1306 - 1315
