N-苄氧羰基六氢-1H-氮杂卓-4-酮合成路线 （共 3 条）
反应条件
potassium hydroxide; water in ethanol 2.5 h; Heating / reflux;
参考文献
PHARMACIA and UPJOHN COMPANY
Patent: EP1173440 B1, 2004 ;
Location in patent: Page 11 ;
EP 1173440 B1
反应条件
potassium carbonate in water; ethyl acetate T=20°C;
参考文献
SEPRACOR INC.; BURDI, Douglas; SPEAR, Kerry, L.; HARDY, Larry, Wendell
Patent: WO2010/114971 A1, 2010 ;
Location in patent: Page/Page column 156 ;
反应条件
1.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 °C / |Inert atmosphere 1.2: 0.5 h / -78 °C / |Inert atmosphere 1.3: |Inert atmosphere 2.1: sodium sulfate; silica gel / hexane; tetrahydrofuran; diethyl ether / 0.17 h / |Inert atmosphere View Scheme
参考文献
Chemistry - A European Journal, , vol. 18, # 38 p. 11889 - 11893
