Regorafenib 盐酸盐合成路线 （共 4 条）
反应条件
hydrogenchloride in tetrahydrofuran; trans-1,3-dioxane
参考文献
BAYER PHARMACEUTICALS CORPORATION
Patent: WO2008/89389 A2, 2008 ;
Location in patent: Page/Page column 15 ;
反应条件
1.1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 4 h 2.1: potassium tert-butylate / N,N-dimethyl acetamide / 0.42 h / 0 °C 2.2: 16 h / 100 °C 3.1: toluene / 72 h / 20 °C 4.1: hydrogenchloride / 1,4-dioxane; tetrahydrofuran View Scheme
参考文献
WO2011/130728 A1, ;
WO 2011/130728 A1
反应条件
1.1: potassium tert-butylate / N,N-dimethyl acetamide / 0.42 h / 0 °C 1.2: 16 h / 100 °C 2.1: toluene / 72 h / 20 °C 3.1: hydrogenchloride / 1,4-dioxane; tetrahydrofuran View Scheme
参考文献
WO2011/130728 A1, ;
WO 2011/130728 A1
反应条件
1: toluene / 72 h / 20 °C 2: hydrogenchloride / 1,4-dioxane; tetrahydrofuran View Scheme
参考文献
WO2011/130728 A1, ;
WO 2011/130728 A1
