2’-氟-5-乙基-beta-D-阿拉伯呋喃基尿嘧啶合成路线 （共 8 条）
反应条件
in methanol; ammonia 65 h;
参考文献
Journal of Organic Chemistry, , vol. 53, p. 85 - 88
反应条件
1: 1,2-dichloro-ethane / 1 h / 100 °C 2: sodium methoxide / methanol / 0.08 h / Heating View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 46, # 4 p. 285 - 289
反应条件
1: 1.) HMDS, ammonium sulfate / 1.) CH3CN, reflux, 3 h, 2.) CHCl3, reflux, 20 h 2: 93 percent / NH3 / methanol / 65 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 5 p. 867 - 871
反应条件
1: (NH4)2SO4 / Heating 2: 8 percent / methanol / 96 h / Ambient temperature 3: NH3 / methanol / 24 h View Scheme
参考文献
Journal of medicinal chemistry, , vol. 27, # 1 p. 91 - 94
反应条件
ammonia in methanol 24 h;
参考文献
Journal of medicinal chemistry, , vol. 27, # 1 p. 91 - 94
反应条件
1: 8 percent / methanol / 96 h / Ambient temperature 2: NH3 / methanol / 24 h View Scheme
参考文献
Journal of medicinal chemistry, , vol. 27, # 1 p. 91 - 94
反应条件
1: 98 percent / HBr / CH2Cl2; acetic acid / 20 h / 20 °C 2: 76.2 percent / CHCl3 / 20 h / Heating 3: 93 percent / liquid ammonia; methanol / 65 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, p. 85 - 88
反应条件
1: 86 percent / pyridine / Ambient temperature
2: P2S5 / dioxane / 3 h / Heating
3: NaOMe / methanol / 1.25 h / Heating
4: methanol; H2O / Ambient temperature
5: 78 percent / NH3 gas / methanol / 29 h / 90 °C
View Scheme
参考文献
Perlman; Watanabe; Schinazi; Fox
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 741 - 748
