1: pyridine / CHCl3 / Ambient temperature 2: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 3: phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 4: 66 percent / LiAlH4 / tetrahydrofuran / Ambient temperature 5: 81 percent / pyridine / Ambient temperature 6: 99 percent / pyridine / CHCl3 / Ambient temperature 7: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 8: t-BuOK / tetrahydrofuran / Ambient temperature 9: dimethylformamide / 80 °C 10: H2 / 5percent Pd/C / tetrahydrofuran / 0.25 h 11: 68.7 percent / pyridine / 72 h / Ambient temperature 12: 98.6 percent / NaH / dimethylformamide / 2 h / 80 °C 13: 88 percent / 1N HCl / dioxane / 1.5 h / 90 °C 14: 79 percent / phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 15: 100 percent / H2 / PdO / methanol; H2O / 1 h / Ambient temperature View Scheme

1: pyridine / CHCl3 / Ambient temperature 2: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 3: phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 4: 66 percent / LiAlH4 / tetrahydrofuran / Ambient temperature 5: 81 percent / pyridine / Ambient temperature 6: 99 percent / pyridine / CHCl3 / Ambient temperature 7: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 8: t-BuOK / tetrahydrofuran / Ambient temperature 9: dimethylformamide / 80 °C 10: 100 percent / pyridine / CHCl3 / 2 h / Ambient temperature 11: 99.4 percent / H2 / 5percent Pd/C / tetrahydrofuran / 0.25 h / Ambient temperature 12: 60 percent / phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature View Scheme

1: pyridine / CHCl3 / Ambient temperature 2: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 3: phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 4: 66 percent / LiAlH4 / tetrahydrofuran / Ambient temperature 5: 78 percent / pyridine / CH2Cl2 / 50 °C 6: 81.5 percent / dimethylsulfoxide / 0.5 h / 140 °C View Scheme

1: pyridine / CHCl3 / Ambient temperature 2: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 3: phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 4: 66 percent / LiAlH4 / tetrahydrofuran / Ambient temperature 5: 81 percent / pyridine / Ambient temperature 6: 99 percent / pyridine / CHCl3 / Ambient temperature 7: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 8: t-BuOK / tetrahydrofuran / Ambient temperature 9: dimethylformamide / 80 °C 10: 75.9 percent / NaH / dimethylformamide / 1.5 h / Ambient temperature 11: 93.8 percent / H2 / 10percent Pd/C / tetrahydrofuran / 0.25 h View Scheme