1: toluene / 1 h / 80 °C 2: pyridine / CHCl3 / Ambient temperature 3: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 4: phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 5: 66 percent / LiAlH4 / tetrahydrofuran / Ambient temperature 6: 81 percent / pyridine / Ambient temperature 7: 99 percent / pyridine / CHCl3 / Ambient temperature 8: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 9: t-BuOK / tetrahydrofuran / Ambient temperature 10: dimethylformamide / 80 °C 11: H2 / 5percent Pd/C / tetrahydrofuran / 0.25 h 12: 68.7 percent / pyridine / 72 h / Ambient temperature 13: 98.6 percent / NaH / dimethylformamide / 2 h / 80 °C 14: 88 percent / 1N HCl / dioxane / 1.5 h / 90 °C 15: 79 percent / phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 16: 100 percent / H2 / PdO / methanol; H2O / 1 h / Ambient temperature View Scheme

1: toluene / 1 h / 80 °C 2: pyridine / CHCl3 / Ambient temperature 3: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 4: phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 5: 66 percent / LiAlH4 / tetrahydrofuran / Ambient temperature 6: 81 percent / pyridine / Ambient temperature 7: 99 percent / pyridine / CHCl3 / Ambient temperature 8: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 9: t-BuOK / tetrahydrofuran / Ambient temperature 10: dimethylformamide / 80 °C 11: 100 percent / pyridine / CHCl3 / 2 h / Ambient temperature 12: 99.4 percent / H2 / 5percent Pd/C / tetrahydrofuran / 0.25 h / Ambient temperature 13: 60 percent / phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature View Scheme

1: toluene / 1 h / 80 °C 2: pyridine / CHCl3 / Ambient temperature 3: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 4: phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 5: 66 percent / LiAlH4 / tetrahydrofuran / Ambient temperature 6: 78 percent / pyridine / CH2Cl2 / 50 °C 7: 81.5 percent / dimethylsulfoxide / 0.5 h / 140 °C View Scheme

1: toluene / 1 h / 80 °C 2: pyridine / CHCl3 / Ambient temperature 3: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 4: phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 5: 66 percent / LiAlH4 / tetrahydrofuran / Ambient temperature 6: 81 percent / pyridine / Ambient temperature 7: 99 percent / pyridine / CHCl3 / Ambient temperature 8: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 9: t-BuOK / tetrahydrofuran / Ambient temperature 10: dimethylformamide / 80 °C 11: 75.9 percent / NaH / dimethylformamide / 1.5 h / Ambient temperature 12: 93.8 percent / H2 / 10percent Pd/C / tetrahydrofuran / 0.25 h View Scheme