(S)-3-Cbz-氨基丁酸合成路线 （共 13 条）
反应条件
silver trifluoroacetate; silica gel in ethyl acetate T=50°C; Wolff rearrangement; 0.25 h;
参考文献
Koch, Karen; Podlech, Joachim
Synthetic Communications, 2005 , vol. 35, # 21 p. 2789 - 2794
反应条件
sodium hydrogencarbonate in 1,4-dioxane; water T=20°C; protection;
参考文献
Attwood, Michael R.; Conway, Elizabeth A.; Dunsdon, Rachel M.; Greening, John R.; Handa, Balraj K.; Jones, Philip S.; Jordan, Steven C.; Keech, Elizabeth; Wilson, Francis X.
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 4 p. 429 - 432
反应条件
1.1: ClCOOEt; N-methylmorpholine / tetrahydrofuran / 0.25 h / -15 °C 1.2: tetrahydrofuran; CH2Cl2 / -15 - 20 °C 2.1: CF3COOAg / dioxane; H2O / 0.5 h / sonication View Scheme
参考文献
Helvetica Chimica Acta, , vol. 89, # 11 p. 2611 - 2637
反应条件
acetic acid; sodium nitrite in dimethyl sulfoxide T=40°C; Nef Reaction; 20 h; Inert atmosphere;
参考文献
Sleebs, Brad E.; Nguyen, Nghi H.; Hughes, Andrew B.
Synlett, 2013 , vol. 24, # 6 art. no. ST-2012-B0741-L, p. 747 - 751
反应条件
sodium hydroxide in methanol 6 h; Ambient temperature;
参考文献
Drey, Charles N. C.; Mtetwa, Eli
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 7 p. 1587 - 1592
反应条件
sodium hydroxide in ethanol 0.5 h; Ambient temperature;
参考文献
Tetrahedron Asymmetry, , vol. 8, # 1 p. 37 - 40
反应条件
1: 1.) Candida antarctica lipase (CAL-SP 435), benzylamine, 2.) aq. Na2CO3 / 1.) toluene, 8 h 2: NaOH / ethanol / 0.5 h / Ambient temperature View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 8, # 1 p. 37 - 40
反应条件
1: potassium fluoride / isopropyl alcohol / 8 h / 0 - 20 °C 2: 4-(N,N-dimethlyamino)pyridine / diethyl ether / 2 h / 25 °C / |Inert atmosphere 3: sodium tetrahydroborate / ethanol / 2 h / 0 °C / |Inert atmosphere 4: sodium nitrite; acetic acid / dimethyl sulfoxide / 20 h / 40 °C / |Inert atmosphere View Scheme
参考文献
Synlett, , vol. 24, # 6 art. no. ST-2012-B0741-L, p. 747 - 751
反应条件
1: 4-(N,N-dimethlyamino)pyridine / diethyl ether / 2 h / 25 °C / |Inert atmosphere 2: sodium tetrahydroborate / ethanol / 2 h / 0 °C / |Inert atmosphere 3: sodium nitrite; acetic acid / dimethyl sulfoxide / 20 h / 40 °C / |Inert atmosphere View Scheme
参考文献
Synlett, , vol. 24, # 6 art. no. ST-2012-B0741-L, p. 747 - 751
反应条件
1.1: sodium tetrahydroborate / methanol; water / 0.25 h / -15 °C / |Inert atmosphere 2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.42 h / -78 °C / |Inert atmosphere 2.2: 0.25 h / -78 °C / |Inert atmosphere 3.1: potassium fluoride / isopropyl alcohol / 8 h / 0 - 20 °C 4.1: 4-(N,N-dimethlyamino)pyridine / diethyl ether / 2 h / 25 °C / |Inert atmosphere 5.1: sodium tetrahydroborate / ethanol / 2 h / 0 °C / |Inert atmosphere 6.1: sodium nitrite; acetic acid / dimethyl sulfoxide / 20 h / 40 °C / |Inert atmosphere View Scheme
参考文献
Synlett, , vol. 24, # 6 art. no. ST-2012-B0741-L, p. 747 - 751
