2-氨基-4,5-二氟苯甲酸合成路线 （共 36 条）
反应条件
hydrogen; palladium hydroxide on carbon in methanol T=20°C; 2 h;
参考文献
WO2003/106435 A1, ;
Page 290; 291; 332 ;
WO 03/106435 A1
反应条件
1: 78 percent / NaOMe, NH2OH*HCl / methanol / 3 h / Ambient temperature 2: p-TsCl, 10percent aq. NaOH View Scheme
参考文献
Synthetic Communications, , vol. 22, # 21 p. 3067 - 3074
反应条件
hydrogenchloride in sodium hydroxide; ethylene glycol dimethyl ether
反应条件
hydrogenchloride; sodium hydroxide; sodium hypochlorite in water
反应条件
potassium fluoride in sulfolane; potassium hydroxide
反应条件
hydrogenchloride; sodium hydroxide; dihydrogen peroxide
反应条件
1: KF / tetrahydrothiophene 1,1-dioxide / 2 h / 185 °C 2: 78 percent / NaOMe, NH2OH*HCl / methanol / 3 h / Ambient temperature 3: p-TsCl, 10percent aq. NaOH View Scheme
参考文献
Synthetic Communications, , vol. 22, # 21 p. 3067 - 3074
参考文献
Kulkarni, Shridhar S.; Singh, Satyakam; Shah, Janki R.; Low, Woon-Kai; Talele, Tanaji T.
European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 264 - 273
反应条件
in ethanol 16 h; Reflux;
参考文献
MERCK PATENT GMBH; Mederski, Werner; Fuchss, Thomas; Zenke, Frank
Patent: US2013/12489 A1, 2013 ;
Location in patent: Paragraph 0203; 0204 ;
