6-甲基氨基-7-甲基-5-硝基喹啉合成路线 （共 11 条）
反应条件
sulfuric acid; nitric acid T=0°C; 1 h;
参考文献
Lee; Hashimoto; Shudo; Okamoto
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 5 p. 1857 - 1859
反应条件
1: 75 percent / HNO3, conc. H2SO4 / 0.5 h / 0 °C 2: 1.) H2SO4, arsenic acid; 2.) H2 / 2.) 10percent Pd-C / 1.) 130 deg C, 18 h; 2.) EtOH, 7 d 3: 90 percent / (CH3CO)2O / 2 h / Ambient temperature 4: 90 percent / LiAlH4 / tetrahydrofuran / 0 °C 5: 68 percent / HNO3, H2SO4 / 1 h / 0 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 30, # 5 p. 1857 - 1859
反应条件
1: 1.) H2SO4, arsenic acid; 2.) H2 / 2.) 10percent Pd-C / 1.) 130 deg C, 18 h; 2.) EtOH, 7 d 2: 90 percent / (CH3CO)2O / 2 h / Ambient temperature 3: 90 percent / LiAlH4 / tetrahydrofuran / 0 °C 4: 68 percent / HNO3, H2SO4 / 1 h / 0 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 30, # 5 p. 1857 - 1859
反应条件
in ethanol; water 4 h; Heating;
参考文献
Adolfsson, Lars; Olsson, Kjell
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1983 , vol. 37, # 2 p. 157 - 159
反应条件
1: 110 mg / 0.17 h / Ambient temperature 2: 500 mg / KNO3, conc. H2SO4 / 0.5 h / Ambient temperature 3: 360 mg / conc. H2SO4 / 0.5 h / 70 °C 4: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 1 h View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 55, # 7 p. 2233 - 2235
反应条件
1: 90 percent / LiAlH4 / tetrahydrofuran / 0 °C 2: 68 percent / HNO3, H2SO4 / 1 h / 0 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 30, # 5 p. 1857 - 1859
反应条件
1: 500 mg / KNO3, conc. H2SO4 / 0.5 h / Ambient temperature 2: 360 mg / conc. H2SO4 / 0.5 h / 70 °C 3: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 1 h View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 55, # 7 p. 2233 - 2235
反应条件
1: 360 mg / conc. H2SO4 / 0.5 h / 70 °C 2: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 1 h View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 55, # 7 p. 2233 - 2235
反应条件
sodium hydride 1.) DMF, RT, 30 min, 2.) DMF, RT, 1 h; Yield given. Multistep reaction;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 55, # 7 p. 2233 - 2235
反应条件
hydrogenchloride; tin(ll) chloride T=100°C; 1 h;
参考文献
Lee; Hashimoto; Shudo; Okamoto
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 5 p. 1857 - 1859
