噻唑-4-甲酰胺腺嘌呤二核苷酸合成路线 （共 8 条）
反应条件
pyridine
T=45°C; 5 h;
参考文献
Gebeyehu; Marquez; Kelley; Cooney; Jayaram; Johns
Journal of Medicinal Chemistry, 1983 , vol. 26, # 6 p. 922 - 925
反应条件
1: 73 percent / 1 N etheral HCl / various solvent(s) / Ambient temperature
2: phosphoryl chloride / various solvent(s) / 3 h / 4 °C
3: 11.4 mg / tri-n-octylamine / 1.) 60 deg C, 2 h, 2.) RT, overnight
4: 1.7 mg / 10percent aq. CH3COOH / 0.42 h / 70 °C
View Scheme
参考文献
Gebeyehu; Marquez; Kelley; Cooney; Jayaram; Johns
Journal of Medicinal Chemistry, 1983 , vol. 26, # 6 p. 922 - 925
反应条件
acetic acid
T=70°C; 0.416667 h;
参考文献
Gebeyehu; Marquez; Kelley; Cooney; Jayaram; Johns
Journal of Medicinal Chemistry, 1983 , vol. 26, # 6 p. 922 - 925
反应条件
1: dimethylformamide / 3 h
2: tri-n-butylamine / dimethylformamide / 48 h / Ambient temperature
View Scheme
参考文献
Gebeyehu; Marquez; van Cott; Cooney; Kelley; Jayaram; Ahluwalia; Dion; Wilson; Johns
Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 99 - 105
反应条件
tributyl-amine in N,N-dimethyl-formamide
48 h; Ambient temperature; Yield given;
参考文献
Gebeyehu; Marquez; van Cott; Cooney; Kelley; Jayaram; Ahluwalia; Dion; Wilson; Johns
Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 99 - 105
参考文献
Gebeyehu; Marquez; van Cott; Cooney; Kelley; Jayaram; Ahluwalia; Dion; Wilson; Johns
Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 99 - 105
反应条件
pyridine; silver nitrate; formamide
36 h;
参考文献
Gebeyehu; Marquez; Kelley; Cooney; Jayaram; Johns
Journal of Medicinal Chemistry, 1983 , vol. 26, # 6 p. 922 - 925
反应条件
1: 11.4 mg / tri-n-octylamine / 1.) 60 deg C, 2 h, 2.) RT, overnight
2: 1.7 mg / 10percent aq. CH3COOH / 0.42 h / 70 °C
View Scheme
参考文献
Gebeyehu; Marquez; Kelley; Cooney; Jayaram; Johns
Journal of Medicinal Chemistry, 1983 , vol. 26, # 6 p. 922 - 925
