2-乙酰基呋喃并-1,4-萘醌合成路线 （共 17 条）
反应条件
1: methyl vinyl ketone With bromine in dichloromethane
0.25 h; Cooling with ice;
2: 2-hydroxynaphthalene-1,4-dione With 1,8-diazabicyclo[5.4.0]undec-7-ene in N,N-dimethyl-formamide
T=20°C; 0.75 h;
参考文献
Zhoushan Haizhongzhou Xinsheng Pharmaceuticals Co., Ltd.; Jiang, Zhiwei; Wang, Aijin; Hu, Hongwei; Xu, Jiali; Hu, Yuesong; Li, Xian; Ye, Yan; Wang, Jie; Li, Qinglong
Patent: US2013/345176 A1, 2013 ;
Location in patent: Paragraph 0149 ;
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in benzene
T=20°C; Reduction; 5 h;
参考文献
Lee; Kim
Synthetic Communications, 2001 , vol. 31, # 3 p. 381 - 386
反应条件
pyridinium chlorochromate
参考文献
Zani, Carlos L.; Oliveira, Alaide B. de; Oliviera, Geovane G. de
Phytochemistry (Elsevier), 1991 , vol. 30, # 7 p. 2379 - 2381
反应条件
ammonium cerium(IV) nitrate in water; acetonitrile
T=0 - 5°C; 0.333333 h;
参考文献
Koyanagi, Jyunichi; Yamamoto, Katsumi; Nakayama, Kouji; Tanaka, Akira
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 2 p. 407 - 412
反应条件
1: With ozone in dichloromethane
T=-78°C;
2: With dimethylsulfide in dichloromethane
T=-78°C; 1 h;
参考文献
Eyong, Kenneth O.; Kumar, Ponminor S.; Kuete, Victor; Folefoc, Gabriel N.; Nkengfack, Ephriam A.; Baskaran, Sundarababu
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5387 - 5390
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran
T=20°C; 10 h;
参考文献
Hagiwara, Hisahiro; Sato, Kouji; Nishino, Daisuke; Hoshi, Takashi; Suzuki, Toshio; Ando, Masayoshi
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 22 p. 2946 - 2957
反应条件
1: 53 percent / ceric ammonium nitrate / acetonitrile / 5 h / 0 °C
2: 95 percent / DBU / benzene / 5 h / 20 °C
View Scheme
参考文献
Lee; Kim
Synthetic Communications, 2001 , vol. 31, # 3 p. 381 - 386
反应条件
chromium(VI) oxide in acetic acid
48 h;
参考文献
Ferreira, V. F.; Pinto, A. V.; Pinto, M. C. F. R.; Cruz, M. C. da; Clarino, A.
Synthetic Communications, 1989 , vol. 19, # 5and6 p. 1061 - 1070
反应条件
1: 80 percent / Hg(OAc)2 / acetic acid / 2 h / Ambient temperature
2: 95 percent / HCl / acetic acid
3: 70 percent / CrO3 / acetic acid / 48 h
View Scheme
参考文献
Ferreira, V. F.; Pinto, A. V.; Pinto, M. C. F. R.; Cruz, M. C. da; Clarino, A.
Synthetic Communications, 1989 , vol. 19, # 5and6 p. 1061 - 1070
反应条件
1: 1.) sodium hydrosulfite, tetrabutylammonium bromide, 2.) KOH / 1.) THF, H2O, RT, 15 min, 2.) THF, H2O, 12 h
2: 1.) BuLi / 1.) THF, hexane, -15 deg C, 4 h, 2.) THF, hexane, RT, 3 h
3: 79 percent / cerium(IV) diammonium nitrate / acetonitrile; H2O / 0.33 h / 0 - 5 °C
View Scheme
参考文献
Koyanagi, Jyunichi; Yamamoto, Katsumi; Nakayama, Kouji; Tanaka, Akira
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 2 p. 407 - 412
