5-(羟基甲基)-3-(1-甲基乙基)恶唑烷-2-酮合成路线 （共 6 条）
反应条件
1: 100 percent / Et3N, (N,N-dimethylamino)pyridine / CH2Cl2 / 2 h / 0 °C 2: 70 percent / benzene / 24 h / Ambient temperature 3: 100 percent / 4 N aq. KOH / benzene / 24 h / Heating View Scheme
参考文献
Cardillo; Orena; Sandri
Journal of Organic Chemistry, 1986 , vol. 51, # 5 p. 713 - 717
反应条件
potassium carbonate in ethanol
12 h; Ambient temperature;
参考文献
Cardillo; Orena; Sandri
Journal of Organic Chemistry, 1986 , vol. 51, # 5 p. 713 - 717
反应条件
1: 70 percent / benzene / 4 h / Heating
2: 98 percent / K2CO3 / ethanol / 12 h / Ambient temperature
View Scheme
参考文献
Cardillo; Orena; Sandri
Journal of Organic Chemistry, 1986 , vol. 51, # 5 p. 713 - 717
反应条件
1: 95 percent / I2 / CHCl3 / 12 h / Ambient temperature
2: 70 percent / benzene / 4 h / Heating
3: 98 percent / K2CO3 / ethanol / 12 h / Ambient temperature
View Scheme
参考文献
Cardillo; Orena; Sandri
Journal of Organic Chemistry, 1986 , vol. 51, # 5 p. 713 - 717
反应条件
sodium methylate in methanol
Industry scale; Product distribution / selectivity;
参考文献
CORDEN PHARMA IP LIMITED; O'NEILL, John, A.; SCHICKANEDER, Helmut; NIKOLOPOULOS, Aggelos; JAS, Gerhard
Patent: WO2010/61366 A1, 2010 ;
Location in patent: Page/Page column 6-7 ;
反应条件
1: 75 percent / dimethylformamide / 5 h / 120 °C
2: 69 percent / 2N NaOH / ethanol / 7 h / Ambient temperature
View Scheme
参考文献
Barraclough, Paul; Gillam, Janet; King, W. Richard; Nebbs, Malcolm S.; Vine, Susan J.
Journal of Chemical Research, Miniprint, 1997 , # 6 p. 1359 - 1376
