2-氨基-5-三氟甲基苯甲酸合成路线 （共 7 条）
反应条件
hydrogenchloride; water in ethanol 3 h; Heating / reflux;
参考文献
WO2004/48314 A1, ;
Page 53-55 ;
反应条件
sodium hydroxide; dihydrogen peroxide T=50°C; 0.5 h;
参考文献
Carmellino; Pagani; Pregnolato; Terreni; Pastoni
European Journal of Medicinal Chemistry, 1994 , vol. 29, # 10 p. 743 - 751
反应条件
1: conc. H2SO4 / 60 - 80 °C 2: 82 percent / 5percent aq. NaOH, 30percent H2O2 / 0.5 h / 50 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 29, # 10 p. 743 - 751
反应条件
1: With hydrogenchloride; sodium nitrite in water T=0 - 5°C; 0.5 h; 2: With sulfuric acid; potassium iodide in water T=10 - 100°C; 2 h;
参考文献
MOCHIDA PHARMACEUTICAL CO., LTD.
Patent: EP1908753 A1, 2008 ;
Location in patent: Page/Page column 107 ;
反应条件
thionyl chloride Reflux;
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 21 p. 8332 - 8338
反应条件
borane-THF in tetrahydrofuran
T=0 - 30°C; 23 h; Inert atmosphere;
参考文献
Ida, Yoshihiro; Matsubara, Ayaka; Nemoto, Toru; Saito, Manabu; Hirayama, Shigeto; Fujii, Hideaki; Nagase, Hiroshi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 19 p. 5810 - 5831
反应条件
pyridine in acetonitrile
T=50°C;
参考文献
F. HOFFMANN-LA ROCHE AG; CECCARELLI, Simona M.; CONTE, Aurelia; KUEHNE, Holger; KUHN, Bernd; NEIDHART, Werner; OBST SANDER, Ulrike; RUDOLPH, Markus
Patent: WO2013/64465 A1, 2013 ;
Location in patent: Page/Page column 186-187 ;
