1-叔丁氧基羰基-3-羟基-吡咯烷合成路线 （共 23 条）
反应条件
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C 2: N,N-dimethyl-formamide / 16 h / 80 °C View Scheme
参考文献
US2011/166121 A1, ;
US 20110166121 A1
反应条件
1: 1-tert-butoxycarbonyl-3-hydroxy-pyrrolidine With sodium hydride in tetrahydrofuran T=0°C; 0.25 h; 2: methyl iodide in tetrahydrofuran T=20°C; 18 h;
参考文献
EVOTEC NEUROSCIENCES GMBH; MADDEN, James; HALLETT, David James; PARKES, Alastair; RAOOF, Ali; WANG, Xialou
Patent: WO2010/20556 A1, 2010 ;
Location in patent: Page/Page column 200-201 ;
WO 2010/020556 A1
反应条件
carbon tetrabromide; triphenylphosphine in tetrahydrofuran T=20°C;
参考文献
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
Patent: WO2007/118830 A1, 2007 ;
Location in patent: Page/Page column 139 ;
WO 2007/118830 A1
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran T=40°C; Condensation; 15 h;
参考文献
Nielsen, Simon Feldbk; Nielsen, Elsebet stergaard; Olsen, Gunnar M.; Liljefors, Tommy; Peters, Dan
Journal of Medicinal Chemistry, 2000 , vol. 43, # 11 p. 2217 - 2226
反应条件
pyridine; acetic anhydride in dichloromethane; ethyl acetate
参考文献
Hansen, Peter; Pettersson, Lars
Patent: US2003/144267 A1, 2003 ;
反应条件
carbon tetrabromide; triphenylphosphine in tetrahydrofuran T=5°C; 0.0833333 h;
参考文献
BUSCH-PETERSEN, Jakob
Patent: US2007/249672 A1, 2007 ;
Location in patent: Page/Page column 21 ;
US 20070249672 A1
反应条件
triethylamine in dichloromethane T=20°C; Cooling with ice;
参考文献
F. HOFFMANN-LA ROCHE AG; BAKER-GLENN, Charles; BURDICK, Daniel Jon; CHAMBERS, Mark; CHEN, Huifen; ESTRADA, Anthony; SWEENEY, Zachary Kevin; CHAN, Bryan K.
Patent: WO2012/62783 A1, 2012 ;
Location in patent: Page/Page column 75 ;
WO 2012/062783 A1
反应条件
in toluene T=3 - 14°C; Product distribution / selectivity;
参考文献
TARGACEPT, INC.; TOLER, Steven M.; HOSFORD, David A.; LIPPIELLO, Patrick M.; DUNBAR, Geoffrey Charles; CALDWELL, William Scott; HAMEDANI, Parviz; BENCHERIF, Merouane
Patent: WO2011/112428 A2, 2011 ;
Location in patent: Page/Page column 28 ;
反应条件
triethylamine; 4-(N,N-dimethlyamino)pyridine in dichloromethane T=20°C; 8 h;
参考文献
PURDUE RESEARCH FOUNDATION; MITSUYA, Hiroaki; KOH, Yasuhiro
Patent: WO2008/133734 A2, 2008 ;
Location in patent: Page/Page column 40 ;
WO 2008/133734 A2
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=23°C; 16 h;
参考文献
Davies, Huw M. L.; Venkataramani, Chandrasekar; Hansen, Tore; Hopper, Darrin W.
Journal of the American Chemical Society, 2003 , vol. 125, # 21 p. 6462 - 6468
