1-(2,2-二甲氧基乙基)环丙醇合成路线 （共 4 条）
反应条件
titanium(IV) isopropylate in diethyl ether
T=25°C; Kulinkovich reaction; 18 h;
参考文献
Limbach, Michael; Dalai, Suryakanta; De Meijere, Armin
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 7 p. 760 - 766
反应条件
1.1: pyridine / CH2Cl2 / 18 h / 20 °C
2.1: aq. HCl / tetrahydrofuran / 0.5 h / 0 °C
3.1: 14.6 g / aq. H2O2 / tetrahydrofuran / 8 h / 60 °C
4.1: SOCl2 / 1,2-dichloro-ethane / 1 h / Heating
4.2: NCS; aq. HCl / 1,2-dichloro-ethane / 12 h / 90 °C
4.3: 93 percent / 1,2-dichloro-ethane / 1 h / 20 °C
5.1: 99 percent / Et3N / CH2Cl2 / 8 h / 0 °C
View Scheme
参考文献
Limbach, Michael; Dalai, Suryakanta; De Meijere, Armin
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 7 p. 760 - 766
反应条件
1: pyridine / CH2Cl2 / 18 h / 20 °C
2: aq. HCl / tetrahydrofuran / 0.5 h / 0 °C
3: 14.6 g / aq. H2O2 / tetrahydrofuran / 8 h / 60 °C
View Scheme
参考文献
Limbach, Michael; Dalai, Suryakanta; De Meijere, Armin
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 7 p. 760 - 766
反应条件
1: pyridine / CH2Cl2 / 18 h / 20 °C
2: aq. HCl / tetrahydrofuran / 0.5 h / 0 °C
3: 14.6 g / aq. H2O2 / tetrahydrofuran / 8 h / 60 °C
4: 83 percent / p-TsOH hydrate / toluene / 6 h / Heating
View Scheme
参考文献
Limbach, Michael; Dalai, Suryakanta; De Meijere, Armin
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 7 p. 760 - 766
