in acetonitrile T=90°C; 10 h;

1: 91 percent / 30percent H2O2, CH3COOH / tetrahydrofuran; H2O / 2 h / -25 - -20 °C 2: 98 percent / p-toluenesulfonic acid / benzene / 2 h / Heating 3: 1.) Me2CuLi, 2.) NH4OH/H2O / 1.) ether, -60 deg C to 0 deg C View Scheme