2′,4′,6′-三甲氧基苯乙酮合成路线 （共 68 条）
反应条件
1: 29 percent Chromat. / AlCl3 / chlorobenzene
2: 60 percent / ethanol / 4 h / Heating
3: 60 percent / H2 / 10percent Pd/C
4: 9 percent / KOH / H2O / 360 h / 4 °C
5: 75 percent / H2 / 10percent Pd/C
View Scheme
参考文献
Malterud, Karl Egil; Undheim, Jorunn; Erdal, John Erik
Tetrahedron Letters, 1985 , vol. 26, # 39 p. 4807 - 4810
参考文献
Mosimann; Tambor
Chemische Berichte, 1916 , vol. 49, p. 1701
反应条件
1: 96 percent / 50 percent aq. KOH / ethanol / 6 h / 20 °C
2: 91 percent / AlCl3 / 10 h / 20 °C
View Scheme
参考文献
Lee, Yean-Jang; Wu, Tsao-Dong
Journal of the Chinese Chemical Society, 2001 , vol. 48, # 2 p. 201 - 206
反应条件
copper(ll) bromide in ethyl acetate
1.5 h; Reflux;
参考文献
TAIVEX THERAPEUTICS CORPORATION; HUANG, Yu-Ling; CHUANG, Shih-Hsien; LEE, Ying-Shuan Eda; HUANG, Jiann-Jyh; LAU, Johnson
Patent: WO2013/82324 A1, 2013 ;
Location in patent: Paragraph 00347 ;
反应条件
potassium hydroxide in methanol
T=70°C; Claisen-Schmidt condensation;
参考文献
Boumendjel, Ahcene; Boccard, Julien; Carrupt, Pierre-Alain; Nicolle, Edwige; Blanc, Madeleine; Geze, Annabelle; Choisnard, Luc; Wouessidjewe, Denis; Matera, Eva-Laure; Dumontet, Charles
Journal of Medicinal Chemistry, 2008 , vol. 51, # 7 p. 2307 - 2310
反应条件
1: methanol / 60 °C
2: dichloro bis(acetonitrile) palladium(II); 1,3-bis-(diphenylphosphino)propane; lithium hydroxide hydrate / 1,4-dioxane / 100 °C / |Sealed tube
View Scheme
参考文献
Roche, Maxime; Hamze, Abdallah; Provot, Olivier; Brion, Jean-Daniel; Alami, Mouad
Journal of Organic Chemistry, 2013 , vol. 78, # 2 p. 445 - 454
反应条件
1: methanol / 60 °C
2: dichloro bis(acetonitrile) palladium(II); sodium t-butanolate; di-tert-butyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine / o-di-fluorobenzene / 100 °C / |Sealed tube
View Scheme
参考文献
Roche, Maxime; Hamze, Abdallah; Provot, Olivier; Brion, Jean-Daniel; Alami, Mouad
Journal of Organic Chemistry, 2013 , vol. 78, # 2 p. 445 - 454
反应条件
1: sodium / 140 °C
2: hydriodic acid
View Scheme
参考文献
Bargellini; Monti
Gazzetta Chimica Italiana, 1915 , vol. 45 I, p. 68
