4-[(1E)-2-(3,5-二甲氧基苯基)乙烯基]-2-甲氧基苯酚合成路线 （共 27 条）
反应条件
potassium tert-butylate; Triton X100.(R). in toluene 3 h; Heating / reflux; Product distribution / selectivity;
参考文献
CLARIANT SPECIALTY FINE CHEMICALS (FRANCE)
Patent: WO2008/12321 A1, 2008 ;
Location in patent: Page/Page column 30-31 ;
反应条件
triethanolamine; palladium diacetate T=100°C; Mizoroki-Heck reaction; 24 h; Inert atmosphere; stereoselective reaction;
参考文献
Csuk, Rene; Albert, Sabrina; Siewert, Bianka; Schwarz, Stefan
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 669 - 678
反应条件
sodium hydride in N,N-dimethyl-formamide T=20°C; 2 h;
参考文献
Matsuda, Hisashi; Morikawa, Toshio; Toguchida, Iwao; Park, Ji-Young; Harima, Shoichi; Yoshikawa, Masayuki
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 1 p. 41 - 50
反应条件
1: With potassium hydroxide; 18-crown-6 ether in dichloromethane T=20°C; Honer-Wadsworth-Emmons reaction; 2: With iodine in n-heptane 12 h; Heating; Further stages.;
参考文献
Kim; Ko; Jae Eun Park; Jung; Sang Kwang Lee; Chun
Journal of Medicinal Chemistry, 2002 , vol. 45, # 1 p. 160 - 164
反应条件
N,N-dicyclohexylmethylamine; tetrabutylammomium bromide; [ClPd(3-OH-5-CH(Me)=N(OH)-phenyl)]2 in N,N-dimethyl acetamide; water T=120°C; Heck reaction; 14 h;
参考文献
Botella, Luis; Najera, Carmen
Tetrahedron, 2004 , vol. 60, # 26 p. 5563 - 5570
反应条件
sodium methylate in N,N-dimethyl-formamide T=100°C; Horner-Wadsworth-Emmons reaction; 1.5 h;
参考文献
Murias, Marek; Handler, Norbert; Erker, Thomas; Pleban, Karin; Ecker, Gerhard; Saiko, Philipp; Szekeres, Thomas; Jaeger, Walter
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 21 p. 5571 - 5578
反应条件
potassium carbonate in acetone 5 h; Heating;
参考文献
Gao, Mingzhang; Wang, Min; Miller, Kathy D.; Sledge, George W.; Hutchins, Gary D.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 22 p. 5767 - 5772
反应条件
in dimethyl sulfoxide 2 h; Heating;
参考文献
Alonso, Emma; Ramon, Diego J.; Yus, Miguel
Journal of Organic Chemistry, 1997 , vol. 62, # 2 p. 417 - 421
反应条件
Grubb's 2nd generation catalyst in dichloromethane Heating;
参考文献
Velder, Janna; Ritter, Stefanie; Lex, Johann; Schmalz, Hans-Guenther
Synthesis, 2006 , # 2 art. no. T08805SS, p. 273 - 278
反应条件
1.1: 90 percent / toluene / 14 h / Heating 2.1: n-BuLi / tetrahydrofuran / 3 h / -78 °C 2.2: tetrahydrofuran / 5 h / 20 °C 3.1: 90 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C 4.1: 92 percent / potassium carbonate / acetone / 5 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 22 p. 5767 - 5772
