3-氨基-2-氰基-5-苯基噻吩合成路线 (共 7 条)
反应条件
0.0833333 h; heating above 200 deg C;
参考文献
Wu-Yun Ren; Rao; Klein
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 6 p. 1757 - 1763
反应条件
sodium hydroxide in ethanol; water 1 h; Reflux;
参考文献
LAILA NUTRACEUTICALS
Patent: US2010/68178 A1, 2010 ;
Location in patent: Page/Page column 19 ;
反应条件
NaOCH3 in ethanol; chloroform
参考文献
Amgen Inc.
Patent: US6187777 B1, 2001 ;
反应条件
1: 3-chloro-3-phenylprop-2-enenitrile With sodium sulfide in N,N-dimethyl-formamide
T=20 - 70°C; 2.08333 h;
2: chloroacetonitrile in N,N-dimethyl-formamide
T=60 - 70°C;
3: With sodium methylate in methanol; N,N-dimethyl-formamide
T=60 - 70°C;
参考文献
LAILA NUTRACEUTICALS
Patent: US2010/68178 A1, 2010 ;
Location in patent: Page/Page column 19 ;
反应条件
di(n-butyl)tin oxide in methanol
0.5 h; Heating;
参考文献
Lim, Mu-Ill; Ren, Wu-Yun; Klein, Robert S.
Journal of Organic Chemistry, 1982 , vol. 47, # 23 p. 4594 - 4595
反应条件
in ethanol
T=-78°C; 0.333333 h;
参考文献
Wu-Yun Ren; Rao; Klein
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 6 p. 1757 - 1763
反应条件
hydrogen sulfide in pyridine; triethylamine
1.) room temperature, 5 min; 2.) 60 deg C, 16 h, sealed vessel;
参考文献
Wu-Yun Ren; Rao; Klein
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 6 p. 1757 - 1763