(2S)-5-溴-3-(2-吡咯烷)吡啶合成路线 （共 14 条）
反应条件
1: With trifluoroacetic acid T=120°C; 0.5 h; Microwave irradiation; 2: With sodium hydrogencarbonate in dichloromethane
参考文献
US2011/15232 A1, ;
Page/Page column 51 ;
反应条件
dimethylsulfide borane complex; cyclohexene in tetrahydrofuran T=-15 - 20°C; 12 h;
参考文献
Felpin, Francois-Xavier; Bertrand, Marie-Jo; Lebreton, Jacques
Tetrahedron, 2002 , vol. 58, # 37 p. 7381 - 7389
反应条件
hydrogenchloride T=110°C; 60 h;
参考文献
McIntee, Edward J.; Hecht, Stephen S.
Chemical Research in Toxicology, 2000 , vol. 13, # 3 p. 192 - 199
反应条件
1: 97 percent / Zn / tetrahydrofuran / 1 h / 20 °C 2: 100 percent / DMP / CH2Cl2 / 0.5 h / 20 °C 3: (+)-B-chlorodiisopinocampheylborane / tetrahydrofuran / -30 °C 4: 100 percent / Et3N / CH2Cl2 / 0.17 h / 0 °C 5: 83 percent / NaN3 / dimethylformamide / 4 h / 60 °C 6: 62 percent / cyclohexene; BH3*Me2S / tetrahydrofuran / 12 h / -15 - 20 °C View Scheme
参考文献
Tetrahedron, , vol. 58, # 37 p. 7381 - 7389
反应条件
1.1: DMF; oxalyl chloride / acetonitrile; tetrahydrofuran; pyridine / 1.5 h / -30 °C 1.2: 63 percent / CuI; tri-tert-butoxyaluminium hydride / acetonitrile; tetrahydrofuran; pyridine / 0.25 h / -78 °C 2.1: 97 percent / Zn / tetrahydrofuran / 1 h / 20 °C 3.1: 100 percent / DMP / CH2Cl2 / 0.5 h / 20 °C 4.1: (+)-B-chlorodiisopinocampheylborane / tetrahydrofuran / -30 °C 5.1: 100 percent / Et3N / CH2Cl2 / 0.17 h / 0 °C 6.1: 83 percent / NaN3 / dimethylformamide / 4 h / 60 °C 7.1: 62 percent / cyclohexene; BH3*Me2S / tetrahydrofuran / 12 h / -15 - 20 °C View Scheme
参考文献
Tetrahedron, , vol. 58, # 37 p. 7381 - 7389
参考文献
Journal of Organic Chemistry, , vol. 47, # 21 p. 4165 - 4167
反应条件
1: 100 percent / DMP / CH2Cl2 / 0.5 h / 20 °C 2: (+)-B-chlorodiisopinocampheylborane / tetrahydrofuran / -30 °C 3: 100 percent / Et3N / CH2Cl2 / 0.17 h / 0 °C 4: 83 percent / NaN3 / dimethylformamide / 4 h / 60 °C 5: 62 percent / cyclohexene; BH3*Me2S / tetrahydrofuran / 12 h / -15 - 20 °C View Scheme
参考文献
Tetrahedron, , vol. 58, # 37 p. 7381 - 7389
反应条件
1: (+)-B-chlorodiisopinocampheylborane / tetrahydrofuran / -30 °C 2: 100 percent / Et3N / CH2Cl2 / 0.17 h / 0 °C 3: 83 percent / NaN3 / dimethylformamide / 4 h / 60 °C 4: 62 percent / cyclohexene; BH3*Me2S / tetrahydrofuran / 12 h / -15 - 20 °C View Scheme
参考文献
Tetrahedron, , vol. 58, # 37 p. 7381 - 7389
反应条件
1: 100 percent / Et3N / CH2Cl2 / 0.17 h / 0 °C 2: 83 percent / NaN3 / dimethylformamide / 4 h / 60 °C 3: 62 percent / cyclohexene; BH3*Me2S / tetrahydrofuran / 12 h / -15 - 20 °C View Scheme
参考文献
Tetrahedron, , vol. 58, # 37 p. 7381 - 7389
反应条件
1: 83 percent / NaN3 / dimethylformamide / 4 h / 60 °C 2: 62 percent / cyclohexene; BH3*Me2S / tetrahydrofuran / 12 h / -15 - 20 °C View Scheme
参考文献
Tetrahedron, , vol. 58, # 37 p. 7381 - 7389
