二氢氯化氟奋乃静-N-2氯乙烷合成路线 （共 6 条）
反应条件
hydrogenchloride; thionyl chloride in chloroform
3 h; Heating;
参考文献
Anderson,E.L. et al.
Arzneimittel Forschung, 1962 , vol. 12, p. 937 - 942
反应条件
1: (i) nBuLi, (ii) /BRN= 1114944/
2: NaI / butan-2-one / 20 h / Heating
3: HCl, SOCl2 / CHCl3 / 3 h / Heating
View Scheme
参考文献
Hirata; Peng; Driscoll
Journal of Pharmaceutical Sciences, 1978 , vol. 67, # 2 p. 157 - 162
反应条件
1: NaI / butan-2-one / 20 h / Heating
2: HCl, SOCl2 / CHCl3 / 3 h / Heating
View Scheme
参考文献
Hirata; Peng; Driscoll
Journal of Pharmaceutical Sciences, 1978 , vol. 67, # 2 p. 157 - 162
反应条件
1: NaI / butan-2-one / 20 h / Heating
2: HCl, SOCl2 / CHCl3 / 3 h / Heating
View Scheme
参考文献
Hirata; Peng; Driscoll
Journal of Pharmaceutical Sciences, 1978 , vol. 67, # 2 p. 157 - 162
反应条件
1: methanol / 1 h / 55 °C
2: SOCl2, HCl / CHCl3 / 3 h / Heating
View Scheme
参考文献
Anderson,E.L. et al.
Arzneimittel Forschung, 1962 , vol. 12, p. 937 - 942
反应条件
1: (i) NaNH2, toluene, (ii) aq. KOH, EtOH
2: methanol / 1 h / 55 °C
3: SOCl2, HCl / CHCl3 / 3 h / Heating
View Scheme
参考文献
Anderson,E.L. et al.
Arzneimittel Forschung, 1962 , vol. 12, p. 937 - 942
