2-溴-4-(溴甲基)吡啶合成路线 （共 5 条）
反应条件
phosphorus tribromide in toluene
T=0 - 100°C; 0.5 h; Inert atmosphere;
参考文献
Biota Europe Ltd.; Lunniss, Christopher James; Palmer, James T.; Pitt, Gary Robert William; Davies, David; Axford, Lorraine Claire
Patent: US2013/252938 A1, 2013 ;
Location in patent: Paragraph 0507 ;
反应条件
1: With acetic acid in tetrachloromethane
T=20 - 50°C;
2: With N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
T=50 - 80°C; 18 h;
参考文献
AVENTIS PHARMA S.A.
Patent: US2004/248884 A1, 2004 ;
Location in patent: Page 121 ;
US 20040248884 A1
反应条件
N-bromosuccinmide in tetrachloromethane
参考文献
Zeneca Limited; Zeneca Pharma S.A.,
Patent: US5962458 A1, 1999 ;
US 5962458 A
参考文献
Merck and Co., Inc.
Patent: US6127390 A1, 2000 ;
US 6127390 A
反应条件
1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C / |Inert atmosphere
2: phosphorus tribromide / toluene / 0.5 h / 0 - 100 °C / |Inert atmosphere
View Scheme
参考文献
Biota Europe Ltd.; Lunniss, Christopher James; Palmer, James T.; Pitt, Gary Robert William; Davies, David; Axford, Lorraine Claire
Patent: US2013/252938 A1, 2013 ;
