FMOC-L-丝氨酸甲酯合成路线 （共 14 条）
反应条件
1: (l)-serine methyl ester hydrochloride With sodium hydrogencarbonate in 1,4-dioxane T=20°C; 0.5 h; 2: 1-[[(9H-fluoren-9-ylmethoxy)carbonyl]oxy]-2,5-pyrrolidinedione in 1,4-dioxane T=20°C; 24 h;
参考文献
Shao, Hui; Lockman, Jeffrey W.; Parquette, Jon R.
Journal of the American Chemical Society, 2007 , vol. 129, # 7 p. 1884 - 1885
反应条件
1: FMOC-SER With potassium carbonate in N,N-dimethyl-formamide T=20°C; 0.5 h; 2: methyl iodide in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
Zhang, Fa; Zhang, Wei; Zhang, Yan; Curran, Dennis P.; Liu, Gang
Journal of Organic Chemistry, 2009 , vol. 74, # 6 p. 2594 - 2597
反应条件
in diethyl ether T=20°C; 0.5 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 22, # 4 p. 1421 - 1428
反应条件
sodium hydrogencarbonate in 1,4-dioxane 0.166667 h; Ambient temperature;
参考文献
Lapatsanis, Lucas; Milias, George; Froussios, Kleanthis; Kolovos, Miltiadis
Synthesis, 1983 , # 8 p. 671 - 673
反应条件
in diethyl ether T=20°C; 0.25 h;
参考文献
Organic letters, , vol. 3, # 16 p. 2477 - 2479
反应条件
1: 72 percent / pyridine / CH2Cl2 / 5 h / Ambient temperature 2: 90 percent / triethylamine / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 60, p. 976 - 980
反应条件
1: 90 percent / CHCl3 2: 90 percent / triethylamine / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 60, p. 976 - 980
反应条件
1: 95 percent / acetone 2: 90 percent / CHCl3 3: 90 percent / triethylamine / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 60, p. 976 - 980
反应条件
in dichloromethane T=20°C;
参考文献
Synthesis, , # 21 p. 3633 - 3641
反应条件
1.1: 94 percent / pyridine 2.1: 92 percent / NaI / acetone / 20 °C 3.1: Zn; 1,2-dibromoethane; Me3SiCl / dimethylformamide / 2 h / 35 °C 3.2: 60 percent / Pd(PPh3)2Cl2 / dimethylformamide 4.1: 85 percent / aq. LiOH / tetrahydrofuran / 20 °C View Scheme
参考文献
Tabanella, Stefania; Valancogne, Ingrid; Jackson, Richard F W
Organic and biomolecular chemistry, 2003 , vol. 1, # 23 p. 4254 - 4261
