3-(4-吡啶基)-3-氧代丙酸甲酯合成路线 （共 11 条）
反应条件
1: carbonic acid dimethyl ester With sodium hydride in tetrahydrofuran T=20°C; 2: 1-(pyridin-4-yl)ethanone in tetrahydrofuran T=20 - 75°C; 5.16667 h;
参考文献
Chemical Communications, , vol. 49, # 15 p. 1521 - 1523
反应条件
sodium hydride 2.5 h; Heating;
参考文献
Journal of the American Chemical Society, , vol. 115, # 25 p. 11705 - 11715
反应条件
1: With potassium tert-butylate T=0 - 50°C; 1.5 h; Inert atmosphere; 2: With hydrogenchloride; water pH=~ 6;
参考文献
WO2011/138250 A1, ;
Page/Page column 7-9 ;
反应条件
1: isonicotinic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran T=20°C; Inert atmosphere; 2: mono-methyl malonate potassium salt With magnesium chloride in tetrahydrofuran T=20°C; Inert atmosphere;
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 5 p. 1868 - 1897
反应条件
in water T=25°C; Equilibrium constant;
参考文献
Journal of the American Chemical Society, , vol. 115, # 25 p. 11705 - 11715
反应条件
1.1: 0.17 h / 0 - 20 °C 1.2: pH ~ 6 2.1: potassium tert-butylate / 1.5 h / 0 - 50 °C / Inert atmosphere 2.2: pH ~ 6 View Scheme
反应条件
1.1: thionyl chloride / 0.17 h / 0 - 20 °C / Inert atmosphere 2.1: 0.17 h / 0 - 20 °C 2.2: pH ~ 6 3.1: potassium tert-butylate / 1.5 h / 0 - 50 °C / Inert atmosphere 3.2: pH ~ 6 View Scheme
参考文献
Moffett,R.B.
Journal of Medicinal Chemistry, 1964 , vol. 7, p. 446 - 449
反应条件
hydrazine in ethanol
参考文献
Arnost, Michael; Pierce, Al; Haar, Ernst ter; Lauffer, David; Madden, Jaren; Tanner, Kirk; Green, Jeremy
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 5 p. 1661 - 1664
