BOC-PHE-PHE-GLY-OH合成路线 （共 14 条）
反应条件
hydrogen; acetic acid; palladium in N,N-dimethyl-formamide
T=20°C; 4 h;
参考文献
Galyuk, E. N.; Egorova, S. V.; Gurina, E. B.; Golubovich, V. P.; Akhrem, A. A.
Chemistry of Natural Compounds, 1992 , vol. 28, # 1 p. 94 - 98
Khimiya Prirodnykh Soedinenii, 1992 , # 1 p. 112 - 117
反应条件
sodium hydroxide in 1,4-dioxane; methanol
0 deg C, 5 h, RT;
参考文献
Michelot; Mayer; Magneney; Pham Van Chuong; Schmitt; Potier
European Journal of Medicinal Chemistry, 1988 , vol. 23, # 3 p. 243 - 247
反应条件
acetic acid; palladium
参考文献
Neubert; Hartrodt; Mehlis; Rueger; Bergmann; Lindau; Jakubke; Barth
Pharmazie, 1985 , vol. 40, # 8 p. 532 - 535
反应条件
sodium hydroxide in methanol; water
T=0°C; 1 h;
参考文献
Lipkowski, Andrzej W.; Misicka, Aleksandra; Drabarek, Stefania
Polish Journal of Chemistry, 1981 , vol. 55, # 4 p. 813 - 818
反应条件
1: ((S)-2-Amino-3-phenyl-propionylamino)-acetic acid; hydrochloride With N-ethyl-N,N-diisopropylamine in water
pH=8.5 - 9; 0.166667 h;
2: Boc-L-Phe-OPfp in tetrahydrofuran; water
3 h;
参考文献
Meneses, Celia; Nicoll, Sarah L.; Trembleau, Laurent
Journal of Organic Chemistry, 2010 , vol. 75, # 3 p. 564 - 569
反应条件
2: CH3COOH / Pd black
View Scheme
参考文献
Neubert; Hartrodt; Mehlis; Rueger; Bergmann; Lindau; Jakubke; Barth
Pharmazie, 1985 , vol. 40, # 8 p. 532 - 535
反应条件
1: Et3N / dimethylformamide / 1.) 2-5 deg C, 1.5 h, 2.) 20 deg C, 3 h
2: 91 percent / H2, AcOH / Pd black / dimethylformamide / 4 h / 20 °C
View Scheme
参考文献
Galyuk, E. N.; Egorova, S. V.; Gurina, E. B.; Golubovich, V. P.; Akhrem, A. A.
Chemistry of Natural Compounds, 1992 , vol. 28, # 1 p. 94 - 98
Khimiya Prirodnykh Soedinenii, 1992 , # 1 p. 112 - 117
反应条件
1: 70 percent / NMM, IBCF / dimethylformamide / -15 °C
2: 85 percent / 1N NaOH / dioxane; methanol / 0 deg C, 5 h, RT
View Scheme
参考文献
Michelot; Mayer; Magneney; Pham Van Chuong; Schmitt; Potier
European Journal of Medicinal Chemistry, 1988 , vol. 23, # 3 p. 243 - 247
反应条件
1: 60 percent / 80percent hydrazine / methanol / 96 h / Ambient temperature
2: 1.) 1M HCl, NaNO2, 2.) triethylamine / 1.) glacial acetic acid, 0 deg C, 15 min, 2.) DMF, 0 deg C, 6 d
View Scheme
参考文献
Koziolkiewicz, Wiktor; Wasiak, Tadeusz; Janecka, Anna
Polish Journal of Chemistry, 1985 , vol. 59, # 7-9 p. 819 - 826
反应条件
1: 4 M HCl / ethyl acetate / 0.25 h / Ambient temperature
2: 81 percent / 1.) triethylamine (TEA), 2.) N-hydroxybenztriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC) / dimethylformamide / 16 h
3: 82 percent / 1 M NaOH / methanol; H2O / 1 h / 0 °C
View Scheme
参考文献
Lipkowski, Andrzej W.; Misicka, Aleksandra; Drabarek, Stefania
Polish Journal of Chemistry, 1981 , vol. 55, # 4 p. 813 - 818
