4-(羟基甲基)双环[2.2.2]辛烷-1-羧酸合成路线 （共 4 条）
反应条件
1: With lithium hydroxide in tetrahydrofuran; methanol; water
T=20 - 25°C; 16 h;
2: With hydrogenchloride in water
pH=0;
参考文献
Biogen, Inc.
Patent: US6649600 B1, 2003 ;
Location in patent: Page/Page column 58 ;
US 6649600 B1
反应条件
1: aq. HCl
2: N2H4*H2O, KOH / bis-(2-hydroxy-ethyl) ether
3: aq. KOH, KMnO4
View Scheme
参考文献
Holtz,H.D.; Stock,L.M.
Journal of the American Chemical Society, 1964 , vol. 86, p. 5183 - 5188
反应条件
1: N2H4*H2O, KOH / bis-(2-hydroxy-ethyl) ether
2: aq. KOH, KMnO4
View Scheme
参考文献
Holtz,H.D.; Stock,L.M.
Journal of the American Chemical Society, 1964 , vol. 86, p. 5183 - 5188
反应条件
potassium hydroxide; potassium permanganate
参考文献
Holtz,H.D.; Stock,L.M.
Journal of the American Chemical Society, 1964 , vol. 86, p. 5183 - 5188
