DL-3-苯基-2-羟丙酸合成路线 （共 84 条）
反应条件
1: 80 percent / pyridine / 6 h / 0 - 5 °C 2: 40 percent / porcine pancreas Type II lipase EC 3.1.1.3; phosphate buffer / acetone / 20 h / 30 °C / pH 7.5 3: bis-Tris buffer; MgCl2; Lactobacillus paracasei DSM 20008 / 42 °C / pH 6.5 View Scheme
参考文献
Larissegger-Schnell, Barbara; Glueck, Silvia M.; Kroutil, Wolfgang; Faber, Kurt
Tetrahedron, 2006 , vol. 62, # 12 p. 2912 - 2916
反应条件
recombinant D-lactate dehydrogenase from Lactobacillus jensenii 269-3; β-NADP+ in aq. phosphate buffer T=25°C; pH=8; Enzymatic reaction;
参考文献
Luyten, Marcel A.; Bur, Daniel; Wynn, Hla; Parris, Wendy; Glod, Marvin; et al.
Journal of the American Chemical Society, 1989 , vol. 111, # 17 p. 6800 - 6804
反应条件
hydrogenchloride T=20°C;
参考文献
Verissimo, Edite; Berry, Neil; Gibbons, Peter; Cristiano, M. Lurdes S.; Rosenthal, Philip J.; Gut, Jiri; Ward, Stephen A.; O'Neill, Paul M.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 14 p. 4210 - 4214
反应条件
toluene-4-sulfonic acid in methanol
参考文献
Abbott Laboratories
Patent: US5164388 A1, 1992 ;
US 5164388 A
参考文献
Bilan, Gal; Gilon, Chaim
Tetrahedron, 1995 , vol. 51, # 38 p. 10513 - 10522
反应条件
potassium carbonate in acetone 1.) room temperature, 1 h, 2.) reflux, overnight; Yield given;
参考文献
Hoffman, Robert V.; Tao, Junhua
Journal of Organic Chemistry, 1997 , vol. 62, # 7 p. 2292 - 2297
反应条件
T=100°C; Electrolysis;
参考文献
Takayama; Matsusaka; Tsubuku
Bulletin of the Chemical Society of Japan, 1942 , vol. 17, p. 45,48, 51
反应条件
pyridine in benzene
3 h; Heating;
参考文献
Kawase, Masami; Setsuo, Saito; Teruo, Kurihara
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 9 p. 1338 - 1343
反应条件
pyridine; hydrogenchloride
1.) benzene, reflux, 3 h, 2.) benzene, 60 deg C, 10 min; Yield given. Multistep reaction;
参考文献
Kawase, Masami; Kurihara, Teruo
Tetrahedron Letters, 1994 , vol. 35, # 44 p. 8209 - 8212
反应条件
carbon in tetrahydrofuran
T=20°C; 8 h;
参考文献
Tang, Liang; Deng, Li
Journal of the American Chemical Society, 2002 , vol. 124, # 12 p. 2870 - 2871
