N-[1-(S)-乙氧羰基-3-苯丙基]-L-丙氨酸合成路线 （共 47 条）
反应条件
sulfuric acid; hydrogen; palladium on activated charcoal in acetic acid T=25 - 30°C; P=760 Torr;
参考文献
Urbach, H.; Henning, R.
Tetrahedron Letters, 1984 , vol. 25, # 11 p. 1143 - 1146
反应条件
hydrogen; palladium in ethanol P=760 Torr; 3 h; Ambient temperature;
参考文献
Hayashi, Kimiaki; Nunami, Ken-ichi; Kato, Jyoji; Yoneda, Naoto; Kubo, Masami; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 289 - 297
反应条件
hydrogen; palladium on activated charcoal in ethanol P=760 Torr; Ambient temperature;
参考文献
Tetrahedron Letters, , vol. 25, # 11 p. 1143 - 1146
反应条件
1: With triethylamine in acetonitrile T=20 - 40°C; 2.5 h; 2: With hydrogen; palladium in ethanol P=1810.07 Torr; 0.2 h;
参考文献
US6395918 B1, ;
Page column 13 ;
反应条件
4-methyl-morpholine in methanol; cyclohexane
反应条件
sodium ethanolate; sodium cyanoborohydride; sodium hydrogencarbonate in ethanol
反应条件
1: 28percent aq. NH3 / 168 h / Ambient temperature 3: CoCl2 / H2O / 72 h / 37 °C / aminoacylase (from Aspergillus oryzae); pH 7 4: SOCl2 5: 43.6 percent / K2CO3 / dimethylsulfoxide / 30 h / Ambient temperature 6: ethyl acetate; diisopropyl ether 7: 96 percent / H2 / Pd / ethanol / 3 h / 760 Torr / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 2 p. 289 - 297
反应条件
2: CoCl2 / H2O / 72 h / 37 °C / aminoacylase (from Aspergillus oryzae); pH 7 3: SOCl2 4: 43.6 percent / K2CO3 / dimethylsulfoxide / 30 h / Ambient temperature 5: ethyl acetate; diisopropyl ether 6: 96 percent / H2 / Pd / ethanol / 3 h / 760 Torr / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 2 p. 289 - 297
反应条件
1: CoCl2 / H2O / 72 h / 37 °C / aminoacylase (from Aspergillus oryzae); pH 7 2: SOCl2 3: 43.6 percent / K2CO3 / dimethylsulfoxide / 30 h / Ambient temperature 4: ethyl acetate; diisopropyl ether 5: 96 percent / H2 / Pd / ethanol / 3 h / 760 Torr / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 2 p. 289 - 297
反应条件
1: SOCl2 2: 43.6 percent / K2CO3 / dimethylsulfoxide / 30 h / Ambient temperature 3: ethyl acetate; diisopropyl ether 4: 96 percent / H2 / Pd / ethanol / 3 h / 760 Torr / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 2 p. 289 - 297
