3-苯基-1H-吡唑-5-胺合成路线 （共 39 条）
反应条件
acetic acid
T=50°C; 1 h;
参考文献
ARRAY BIOPHARMA INC.; GENENTECH, INC.; GRADL, Stefan; RUDOLPH, Joachim; REN, Li
Patent: WO2011/25951 A1, 2011 ;
Location in patent: Page/Page column 49 ;
WO 2011/025951 A1
反应条件
acetic acid
T=22 - 40°C; 16 h;
参考文献
Ren, Li; Laird, Ellen R.; Buckmelter, Alex J.; Dinkel, Victoria; Gloor, Susan L.; Grina, Jonas; Newhouse, Brad; Rasor, Kevin; Hastings, Gregg; Gradl, Stefan N.; Rudolph, Joachim
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 1165 - 1168
参考文献
Balicki, Roman; Nantka-Namirski, Pawel
Polish Journal of Chemistry, 1982 , vol. 56, # 7/8/9 p. 963 - 973
参考文献
Balicki, Roman; Nantka-Namirski, Pawel
Polish Journal of Chemistry, 1982 , vol. 56, # 7/8/9 p. 963 - 973
反应条件
in ethanol
2.5 h; Ambient temperature;
参考文献
Parkanyi, Cyril; Abdelhamid, Abdou O.; Cheng, John C. S.
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 1029 - 1032
反应条件
acetic acid
T=180°C; 0.333333 h; Microwave irradiation;
参考文献
SCHERING CORPORATION; SHIPPS, JR., Gerald, W.; CHENG, Cliff, C.; HUANG, Xiaohua; ACHAB, Abdelghani, Abe; ORTH, Peter; VOIGT, Johannes, H.; SOUCY, Kyle, Ann
Patent: WO2010/56631 A1, 2010 ;
Location in patent: Page/Page column 110 ;
WO 2010/056631 A1
反应条件
N-chloro-succinimide in methanol; chloroform; acetonitrile
参考文献
CHEMOCENTRYX, INC.
Patent: WO2003/105853 A1, 2003 ;
Location in patent: Page 66-67 ;
WO 03/105853 A1
反应条件
1: HCl, NaNO2
2: 88 percent / sodium acetate / ethanol / Ambient temperature
View Scheme
参考文献
El-Ghandour, Ahmed Hafez Hussein; Ibrahim, Mohamed Kamal Ahmed; Abdel-Hafiz, Ibrahim Saad; Elnagdi, Mohamed Hilmy
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1992 , vol. 47, # 11 p. 1628 - 1632
反应条件
hydrogenchloride; sodium nitrite
T=-5°C;
参考文献
Sadchikova, Elena V.; Bakulev, Vasiliy A.; Subbotina, Julia O.; Privalova, Darya L.; Dehaen, Wim; Van Hecke, Kristof; Robeyns, Koen; Van Meervelt, Luc; Mokrushin, Vladimir S.
Tetrahedron, 2013 , vol. 69, # 34 p. 6987 - 6992
