α-N,N-二甲氨基苯乙腈合成路线 （共 42 条）
参考文献
Stevens; Cowan; MacKinnon
Journal of the Chemical Society, 1931 , p. 2568,2571
反应条件
1: With trifluorormethanesulfonic acid in dichloromethane
T=60 - 80°C; Houben-Housch synthesis; Inert atmosphere;
2: With water in dichloromethane
Houben-Housch synthesis; Inert atmosphereCooling with ice;
3: With sodium hydroxide in water
Inert atmosphere;
参考文献
Raja, Erum K.; Klumpp, Douglas A.
Tetrahedron, 2011 , vol. 67, # 25 p. 4494 - 4497
反应条件
1: With sodium ethanolate in ethanol
2: With copper(II) sulfate in ethanol; water
参考文献
Pohmakotr, Manat; Sampaongoen, Laddawan; Issaree, Arisara; Tuchinda, Patoomratana; Reutrakul, Vichai
Tetrahedron Letters, 2003 , vol. 44, # 35 p. 6717 - 6720
反应条件
2: 30percent aq. oxalic acid / tetrahydrofuran / 1.5 h / Heating
View Scheme
参考文献
Takahashi, Kazumasa; Matsuzaki, Masahiro; Ogura, Katsuyuki; Iida, Hirotada
Journal of Organic Chemistry, 1983 , vol. 48, # 11 p. 1909 - 1912
反应条件
1: NaOH, tetraalkylammonium halide / dimethylsulfoxide
2: aq. HCl
View Scheme
参考文献
Zdrojewski, T.; Jonczyk, A.
Synthesis, 1990 , # 3 p. 224 - 233
反应条件
sodium amide in ammonia
T=-70°C; 0.0333333 h; Yields of byproduct given;
参考文献
Makosza, Mieczyslaw; Stalinski, Krzysztof
Tetrahedron, 1998 , vol. 54, # 30 p. 8797 - 8810
反应条件
1: 1.) n-BuLi / 1.) THF, -78 deg C, 15 min, 2.) THF, -78 deg C
2: 90 percent / 0.5 N aqueous AgNO3 / diethyl ether; tetrahydrofuran / 0.5 h / Ambient temperature
View Scheme
参考文献
Zervos, M.; Wartski, L.
Tetrahedron Letters, 1984 , vol. 25, # 41 p. 4641 - 4644
参考文献
Zervos, Michel; Wartski, Lya; Seyden-Penne, Jacqueline
Tetrahedron, 1986 , vol. 42, # 18 p. 4963 - 4974
反应条件
2: 98 percent / 30percent aq. oxalic acid / tetrahydrofuran / 1.5 h / Heating
View Scheme
参考文献
Takahashi, Kazumasa; Matsuzaki, Masahiro; Ogura, Katsuyuki; Iida, Hirotada
Journal of Organic Chemistry, 1983 , vol. 48, # 11 p. 1909 - 1912
参考文献
Stevens; Cowan; MacKinnon
Journal of the Chemical Society, 1931 , p. 2568,2571
