1: With AlCl3, aluminium chloride
T=75°C; 0.333333 h; Inert atmosphere;
2: With bromine
T=75°C; 0.333333 h;
3: With hydrogenchloride in water
0.5 h; Cooling with ice;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; THOMPSON III, Lorin A.; SHI, Jianliang; WU, Yong-Jin; MARCIN, Lawrence R.; RAJAMANI, Ramkumar; HIGGINS, Mendi A.
Patent: WO2012/162330 A1, 2012 ;
Location in patent: Page/Page column 24 ;
1: potassium nitrate; sulfuric acid / 1.5 h / 0 °C / |Cooling with ice
2: hydrogenchloride; tin / ethanol / 0.83 h / |Reflux
3: sodium nitrite; sulfuric acid / water / 0.5 h / 0 °C
View Scheme