alpha,alpha-二甲基苯乙酸合成路线 （共 89 条）
反应条件
lithium aluminium tetrahydride in diethyl ether
Reduction;
参考文献
Di Giacomo, Barbara; Coletta, Donato; Natalini, Benedetto; Ni, Ming-Hong; Pellicciari, Roberto
Farmaco, 1999 , vol. 54, # 9 p. 600 - 610
反应条件
in tetrahydrofuran; methanol; water
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
Title/Abstract Full Text Show Details
Vertex Pharmaceuticals Incorporated
Patent: US2012/309758 A1, 2012 ;
US 20120309758 A1
反应条件
AgF*HF; Titanium(IV) oxide in acetonitrile
Irradiation;
参考文献
Lai, Cuiwei; Kim, Yeong Il; Wang, Chong Mou; Mallouk, Thomas E.
Journal of Organic Chemistry, 1993 , vol. 58, # 6 p. 1393 - 1399
反应条件
1: methyllithium With copper (I) cyanide in diethyl ether
T=0°C; 0.0833333 h; Inert atmosphere;
2: α,α-Dimethyl-phenylacetic acid in diethyl ether
T=0 - 20°C; 15 h; Inert atmosphere;
参考文献
Genna, Douglas T.; Posner, Gary H.
Organic Letters, 2011 , vol. 13, # 19 p. 5358 - 5361
反应条件
(i) SOCl2, (ii) aq. NH3; Multistep reaction;
参考文献
Zalesskaya,T.E.; Remizova,T.B.
J. Gen. Chem. USSR (Engl. Transl.), 1964 , vol. 34, p. 3168 - 3173,3215 - 3219
反应条件
in 2-methyl tetrahydrofuran
T=23°C; 2 h; Inert atmosphere;
参考文献
Dunn, Peter J.; Hoffmann, Wilfried; Kang, Ying; Mitchell, John C.; Snowden, Martin J.
Organic Process Research and Development, 2005 , vol. 9, # 6 p. 956 - 961
反应条件
sodium azide; chloroformic acid ethyl ester; triethylamine
1.) acetone, 10 deg C,2 h, 2.) H2O, 10 deg C, 6 h, benzene, 3.) reflux, 4 h; Yield given. Multistep reaction;
参考文献
Leffler, J. E.; Zupancic, J. J.
Journal of the American Chemical Society, 1980 , vol. 102, # 1 p. 259 - 267
反应条件
1: 0.17 h / 20 °C
2: 2-hydroxy-5-nitro-pyridine / 1-Propyl acetate / 24 h / 102 °C
View Scheme
参考文献
Dunn, Peter J.; Hoffmann, Wilfried; Kang, Ying; Mitchell, John C.; Snowden, Martin J.
Organic Process Research and Development, 2005 , vol. 9, # 6 p. 956 - 961
反应条件
(i) SOCl2, (ii) Li<AlH(OtBu)3>, THF; Multistep reaction;
参考文献
Gising, Johan; Nilsson, Mikael T.; Odell, Luke R.; Yahiaoui, Samir; Lindh, Martin; Iyer, Harini; Sinha, Achyut M.; Srinivasa, Bachally R.; Larhed, Mats; Mowbray, Sherry L.; Karlen, Anders
Journal of Medicinal Chemistry, 2012 , vol. 55, # 6 p. 2894 - 2898
