bis(trichloromethyl) carbonate in dichloromethane T=20°C; 72 h;

hydrogenchloride in diethyl ether

1: With n-butyllithium; bis(diethylamino)phosphorochloridite 2: With n-butyllithium; bis(diethylamino)phosphorochloridite 3: With hydrogenchloride Further stages.;

1: diethyl ether 2: 80 percent / HCl / diethyl ether View Scheme

1: 1) BuLi / 1) ether, n-hexane; 2) ether 2: 80 percent / HCl / diethyl ether View Scheme

1: 80 percent / diethyl ether 2: 1) BuLi / 1) ether, n-hexane; 2) ether 3: 80 percent / HCl / diethyl ether View Scheme

1: BuLi 2: HCl View Scheme

in tetrahydrofuran T=60°C; 12 h; Inert atmosphere;

lithium aluminium tetrahydride in diethyl ether 1.) 30 min, 2.) reflux, 2 h;

1.1: 1,1-dimethylethylmagnesium chloride / tetrahydrofuran; diethyl ether / 4 h / -78 - 20 °C / Inert atmosphere 2.1: magnesium / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere 3.1: {Pd[(S)-N,N-dimethyl-1-(2-naphthyl)ethylamine](μ-Cl)}2 / dichloromethane / 0.33 h / 20 °C / Resolution of racemate 3.2: 20 °C / Resolution of racemate 4.1: air / dichloromethane / 1 h 4.2: 2 h / -78 - 20 °C View Scheme