2-氯-4,6-二甲氧基苯胺合成路线 （共 7 条）
反应条件
hydrogenchloride in diethyl ether T=-10 - 0°C; 1 h;
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 11 p. 2816 - 2825
反应条件
hydrogenchloride T=25 - 30°C;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1095 - 1098
反应条件
1: KNO2; sulfuric acid; sodium hydroxide / water / 2 h / -3 - 0 °C 2: hydrogenchloride / diethyl ether / 1 h / -5 - 0 °C View Scheme
参考文献
Synthesis, , # 7 p. 1045 - 1054
反应条件
1: KNO2; sulfuric acid; sodium hydroxide / water / 2 h / -3 - 0 °C 2: chloro-trimethyl-silane / diethyl ether / 1 h / -5 - 0 °C View Scheme
参考文献
Synthesis, , # 7 p. 1045 - 1054
反应条件
hydrogenchloride; diethyl ether
参考文献
Chemische Berichte, , vol. 90, p. 19,25
Bl. Fac. Eng. Hiroshima Univ.Chem.Abstr., , vol. 7, p. 101,104
Bl. Fac. Eng. Hiroshima Univ.Chem.Abstr., , p. 11839
反应条件
1: 92 percent / 1.) conc. hydrochloric acid, sodium nitrite, 2.) phosphinous acid / dioxane; H2O / 20 h / 0 °C 2: 2.0 g / phosphoryl chloride / 0 deg C; room temperature, 0.5 h; 3 h View Scheme
参考文献
Sargent, Melvyn V.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1095 - 1098
反应条件
hydrogenchloride; hypophosphorous ether; sodium nitrite in 1,4-dioxane; water T=0°C; 20 h;
参考文献
Sargent, Melvyn V.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1095 - 1098
