(3-氯-5-甲氧基苯基)甲醇合成路线 （共 7 条）
反应条件
20 PCC/alumina 1.25 h;
参考文献
Vertex Pharmaceuticals Incorporated
Patent: US2010/272681 A1, 2010 ;
反应条件
hydrogenchloride; sodium tetrahydroborate in ethanol
参考文献
Arstad, Erik; Henriksen, Gjermund
Patent: US2009/155168 A1, 2009 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
2 h;
2: With hydrogenchloride in tetrahydrofuran; water
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/39736 A1, 2007 ;
Location in patent: Page/Page column 40 ;
WO 2007/039736 A1
反应条件
hydrogenchloride; hypophosphorous ether; sodium nitrite in 1,4-dioxane; water
T=0°C; 20 h;
参考文献
Sargent, Melvyn V.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1095 - 1098
反应条件
1: 1.) hydrogen chloride gas, 2.) conc. hydrochloric acid, sodium nitrite, 3.) phosphinous acid / 1.) 25 deg C-30 deg C, 2.) dioxan, water, 0 deg C, 20 h
2: 54 percent / 1.) conc. hydrochloric acid, sodium nitrite, 2.) phosphinous acid / dioxane; H2O / 20 h / 0 °C
View Scheme
参考文献
Sargent, Melvyn V.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1095 - 1098
反应条件
phosphorus tribromide in diethyl ether
T=0°C; 0.5 h;
参考文献
ASTRAZENECA AB
Patent: US2008/293775 A1, 2008 ;
Location in patent: Page/Page column 23 ;
US 20080293775 A1
参考文献
ASTRAZENECA AB
Patent: US2008/293775 A1, 2008 ;
Location in patent: Page/Page column 44 ;
US 20080293775 A1
