2-羟基-3-甲基苯甲醛合成路线 （共 54 条）
反应条件
7,8-difluoro-1,3-dimethyl-5-ethyl-4a-hydroperoxyalloxazine; dihydrogen peroxide; sodium hydrogencarbonate in methanol; water T=20°C; Dakin oxidation; 3 h;
参考文献
Chen, Shuai; Hossain, Mohammad S.; Foss, Frank W.
Organic Letters, 2012 , vol. 14, # 11 p. 2806 - 2809
反应条件
1: 80 percent / NaBH4 2: 70 percent / PCl3, pyridine / diethyl ether / -10 deg C, 1.5 h, r.t., 2 h, 0 deg C, 12 h View Scheme
参考文献
Lorey, Martina; Meier, Chris; De Clercq, Eric; Balzarini, Jan
Nucleosides and Nucleotides, 1997 , vol. 16, # 7-9 p. 1307 - 1310
反应条件
sodium acetate T=175 - 180°C; 6 h;
参考文献
TORRENT PHARMACEUTICALS LTD.
Patent: WO2008/149379 A2, 2008 ;
Location in patent: Page/Page column 52-53 ;
WO 2008/149379 A2
参考文献
TORRENT PHARMACEUTICALS LTD.
Patent: US2010/168110 A1, 2010 ;
Location in patent: Page/Page column 19 ;
反应条件
pyrrolidine; copper(l) iodide in acetonitrile T=100°C; 2 h;
参考文献
Reddy, Maddi Sridhar; Thirupathi, Nuligonda; Haribabu, Madala
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 180 - 184
反应条件
in acetic anhydride T=180 - 190°C; 5 h;
参考文献
Valenti; Rampa; Budriesi; Bisi; Chiarini
Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 6 p. 803 - 810
反应条件
1.1: BuLi / hexane; tetrahydrofuran / 2 h / 0 °C 1.2: 90 percent / hexane; tetrahydrofuran / -78 °C 2.1: 75 percent / K2CO3 / dimethylformamide 3.1: 81 percent / Grubbs second-generation catalyst / CH2Cl2 / 20 °C View Scheme
参考文献
Polito, Laura; Cravini, Massimiliano; Poletti, Laura; Lay, Luigi
Synthetic Communications, 2006 , vol. 36, # 15 p. 2203 - 2209
反应条件
in tetrahydrofuran; dichloromethane Heating;
参考文献
Anwar, Hany F.; Skattebol, Lars; Skramstad, Jan; Hansen, Trond Vidar
Tetrahedron Letters, 2005 , vol. 46, # 32 p. 5285 - 5287
反应条件
alkali hydroxide; hydrazine hydrate; diethylene glycol
参考文献
Wessely et al.
Monatshefte fuer Chemie, 1950 , vol. 81, p. 1071,1083
反应条件
1: 2-Hydroxy-3-methyl-benzaldehyde With potassium carbonate in N,N-dimethyl-formamide T=20°C; 0.25 h; Inert atmosphere; 2: alpha-bromoacetonitrile in N,N-dimethyl-formamide Inert atmosphere;
参考文献
Organic Letters, , vol. 12, # 2 p. 352 - 355
