6-溴-2,2-二甲基-2H-苯并吡喃合成路线 （共 20 条）
反应条件
n-butyllithium 1.) THF, -78 deg C, 2.) THF; Yield given. Multistep reaction;
参考文献
Zhang, Xuqing; Li, Xiaojie; Sui, Zhihua
Patent: US2007/49556 A1, 2007 ;
Location in patent: Page/Page column 32-33 ;
反应条件
n-butyllithium in tetrahydrofuran; hexane; ethyl acetate
参考文献
Pfizer Inc.
Patent: US5677324 A1, 1997 ;
US 5677324 A
反应条件
n-butyllithium 1.) hexane, ether, RT, 1 h, 2.) hexane, ether, RT, 30 h; Yield given. Multistep reaction;
参考文献
Alberola, Angel; Calvo, Blanca; Gonzalez-Ortega, Alfonso; Lopez, Cristina; Villafane, Fernando
Heterocycles, 1994 , vol. 38, # 4 p. 819 - 832
反应条件
N,N-diethylaniline
T=190°C; 3 h;
参考文献
Bristol-Myers Squibb Company
Patent: US5869478 A1, 1999 ;
US 5869478 A
反应条件
boron trifluoride diethyl etherate in dichloromethane
T=20°C; 6.5 h;
参考文献
Madabhushi, Sridhar; Jillella, Raveendra; Godala, Kondal Reddy; Mallu, Kishore Kumar Reddy; Beeram, China Ramanaiah; Chinthala, Narsaiah
Tetrahedron Letters, 2012 , vol. 53, # 39 p. 5275 - 5279
反应条件
1: With ArgoGelR-NH2-supported arylselenyl bromide in water
T=20°C;
2: With dihydrogen peroxide in water
T=20°C;
参考文献
Fujita, Ken-Ichi; Hashimoto, Shigeru; Oishi, Akihiro; Taguchi, Yoichi
Tetrahedron Letters, 2003 , vol. 44, # 19 p. 3793 - 3795
反应条件
potassium hydrogensulfate
T=100 - 125°C; Dehydration; P=10 Torr;
参考文献
Clayton, Stephen E.; Guinot, Stephane G.R.; Hepworth, John D.; Wainwright, Mark
Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 2 p. 263 - 269
反应条件
1: With ytterbium(III) triflate in dichloromethane
T=20°C; 60 h;
2: With toluene-4-sulfonic acid in toluene
1 h; Heating;
参考文献
Prado, Soizic; Janin, Yves L.; Bost, Pierre-Etienne
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 6 p. 1605 - 1608
反应条件
RhCl3 hydrate; 1,3-bis-(diphenylphosphino)propane in diethylene glycol dimethyl ether
T=200°C; 0.5 h; Microwave irradiation;
参考文献
Broehmer, Manuel C.; Volz, Nicole; Braese, Stefan
Synlett, 2009 , # 9 p. 1383 - 1386
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=130°C; 8 h;
参考文献
Kawase, Yoshiyuki; Yamaguchi, Seiji; Horita, Hisanori; Takeno, Junko; Kameyama, Hideaki
Bulletin of the Chemical Society of Japan, 1982 , vol. 55, # 4 p. 1153 - 1155
