2-(羟基亚甲基)环己酮合成路线 （共 42 条）
反应条件
potassium hydroxide in methanol 1) 5 h, r.t., then 2 h, reflux;
参考文献
Ravikumar, V. T.; Sathyamoorthi, G.; Thangaraj, K.; Rajagopalan, K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 959
反应条件
1: 1.) NaNO2, conc. HCl; 2.) 50percent KOH aq. / 1.) water; 2.) EtOH, r.t., 30 min 2: 1.356 g / acetic acid / 0.75 h / Heating View Scheme
参考文献
Murakami; Ishii
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 3 p. 699 - 710
反应条件
1: sodium acetate / methanol; water View Scheme
参考文献
Chakraborty, Suchandra; Chattopadhyay, Gautam; Saha, Chandan
Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 2 p. 331 - 338
反应条件
1: 4-chloro-aniline With hydrogenchloride; sodium nitrite in water T=0°C; 0.833333 h; 2: 2-hydroxymethylidenecyclohexanone With sodium acetate in methanol; water T=0°C; 0.583333 h;
参考文献
WO2004/110999 A1, ;
Page 27-28 ;
反应条件
1: 4-amino-phenol With hydrogenchloride; sodium nitrite in water T=0°C; 0.833333 h; 2: 2-hydroxymethylidenecyclohexanone With sodium acetate in methanol; water 0.5 - 0.583333 h;
参考文献
WO2005/5386 A1, ;
Page 27-28 ;
反应条件
sodium acetate in methanol; water
参考文献
Journal of Heterocyclic Chemistry, , vol. 48, # 2 p. 331 - 338
反应条件
potassium hydroxide in methanol 5 h; Ambient temperature;
参考文献
Ravikumar, V. T.; Sathyamoorthi, G.; Thangaraj, K.; Rajagopalan, K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 959
反应条件
potassium hydroxide in methanol 5 h; Ambient temperature;
参考文献
Ravikumar, V. T.; Sathyamoorthi, G.; Thangaraj, K.; Rajagopalan, K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 959
反应条件
1: K2CO3 / dimethylsulfoxide / 12 h / 50 °C 2: 2) 2 N H2SO4 / 1) THF, 0 degC, 1.5 h, 2) EtOH, 25 degC, 3 h View Scheme
参考文献
Marvell, Elliot N.; Hilton, Charles; Cleary, Michael
Journal of Organic Chemistry, 1983 , vol. 48, # 23 p. 4272 - 4275
反应条件
1: (i) Mg, Et2O, (ii) /BRN= 970863/ 2: diethyl ether 3: (i) polyphosphoric acid, (ii) Pd-C, 1,3,5-trimethyl-benzene View Scheme
参考文献
Wysocka,W. et al.
Synthesis, 1977 , p. 261 - 263
