2-氨基-3,4-二甲基吡啶合成路线 (共 10 条)
反应条件
trifluoroacetic acid in dichloromethane T=0 - 20°C;
参考文献
WO2010/72722 A1, ;
Page/Page column 31 ;
WO 2010/072722 A1
参考文献
The Ohio State University Research Foundation
Patent: US3985756 A1, 1976 ;
反应条件
sodium amide in various solvent(s) T=145 - 155°C; 6.5 h; Yield given;
参考文献
Journal of Heterocyclic Chemistry, , vol. 18, p. 1613 - 1618
反应条件
1: CH2Cl2 / Heating 2: conc. HCl View Scheme
参考文献
Bioorganic and medicinal chemistry letters, , vol. 10, # 17 p. 1975 - 1978
反应条件
acetic anhydride in dichloromethane
参考文献
Merck and Co., Inc.
Patent: US5972975 A1, 1999 ;
反应条件
pyridine in 1,4-dioxane; ethanol; n-heptane; ethyl acetate
参考文献
Invitrogen Corporation, a Delaware corporation
Patent: US2006/8855 A1, 2006 ;
US 20060008855 A1
参考文献
Reilly Tar and Chemical Corporation
Patent: US4386209 A1, 1983 ;
反应条件
sodium hydroxide in tetrahydrofuran; dichloromethane
参考文献
Dong Kook Pharmaceutical Co., Ltd.
Patent: US6127546 A1, 2000 ;
反应条件
sulfuric acid; nitric acid
a) RT, 12 h, b) 95 deg C, 2 h;
参考文献
Straub
Synthetic Communications, 1993 , vol. 23, # 3 p. 365 - 372