4-羟基-7-甲氧基喹啉合成路线 （共 10 条）
反应条件
1: With potassium hydroxide in water; ethylene glycol T=200°C; P=11377.6 - 12411.9 Torr; 0.5 h; 2: With hydrogenchloride in water; ethylene glycol pH=~ 6; Product distribution / selectivity;
参考文献
PFIZER INC.
Patent: WO2005/21553 A1, 2005 ;
Location in patent: Page/Page column 77 ;
WO 2005/021553 A1
反应条件
in diphenylether 1 h; Reflux;
参考文献
Nsumiwa, Samkele; Kuter, David; Wittlin, Sergio; Chibale, Kelly; Egan, Timothy J.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3738 - 3748
反应条件
in diphenylether T=225 - 260°C; 0.0833333 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/134378 A1, 2006 ;
Location in patent: Page/Page column 56 ;
WO 2006/134378 A1
反应条件
in diphenylether T=250°C; 0.75 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2003/99274 A1, 2003 ;
Location in patent: Page 513-514 ;
WO 03/099274 A1
反应条件
1.1: toluene / 1 h / Heating 1.2: 14 percent / diphenyl ether / 12 h / 230 °C 2.1: aq. sodium hydroxide / 1 h / Heating 3.1: diphenyl ether / 1 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 55, # 5 p. 821 - 824
反应条件
1: diphenyl ether / Heating 2: 2 N NaOH / Heating 3: diphenyl ether / 1 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 25 p. 4918 - 4926
反应条件
trichlorophosphate T=140°C; 0.333333 h;
参考文献
Nsumiwa, Samkele; Kuter, David; Wittlin, Sergio; Chibale, Kelly; Egan, Timothy J.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3738 - 3748
反应条件
phosphorus oxytribromide T=110°C; 3 h;
参考文献
US2004/248884 A1, ;
Page 105 ;
US 20040248884 A1
反应条件
1: trichlorophosphate / 0.33 h / 140 °C 2: ammonium hydroxide; zinc(II) chloride / 1.5 h / 160 - 180 °C / 15376.5 Torr / |Microwave irradiation View Scheme
参考文献
Nsumiwa, Samkele; Kuter, David; Wittlin, Sergio; Chibale, Kelly; Egan, Timothy J.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3738 - 3748
反应条件
1: POCl3 / 1.17 h / 100 - 110 °C
2: a) 80-100 deg C, 1 h, b) 135-150 deg C, 8 h
View Scheme
参考文献
De, Dibyendu; Krogstad, Frances M.; Byers, Larry D.; Krogstad, Donald J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 25 p. 4918 - 4926
